Somatic transgenesis by immunoglobulin genes

Dr. Maurizio; Zanetti

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Somatic transgenesis by immunoglobulin genes

机译：免疫球蛋白基因的体细胞转基因

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In this chapter we describe and discuss somatic transgenesis produced in adult immunocompetent mice using plasmid DNA containing immunoglobulin genes under control of tissue-specific regulatory elements. We review our experience to date and discuss the findings in relation to the known rules for intracellular usage of immunoglobulin genes in activated and differentiated B cells. Because immunoglobulin genes are controlled by B lymphocytes specific promoter and enhancer elements, somatic transgenesis is a new approach to selective targeting of B lymphocytes in vivo for transcription and long-term expression of exogenous immunoglobulin genes. Owing to the fact that transgenic immunoglobulins synthesized and secreted in vivo are immunogenic for the host and that immunoglobulin genes can be engineered to code for heterologous epitopes, ligands or receptors, somatic transgenesis offers unique features for the development of new strategies of DNA-based immunization and gene therapy.

机译：在本章中，我们描述和讨论在成年免疫能力强的小鼠中使用组织特异性调节元件控制下的含有免疫球蛋白基因的质粒DNA产生的体细胞转基因。我们回顾了迄今为止的经验，并讨论了有关激活和分化B细胞中免疫球蛋白基因在细胞内使用的已知规则的发现。因为免疫球蛋白基因受B淋巴细胞特异性启动子和增强子元件的控制，所以体细胞转基因是在体内选择性靶向B淋巴细胞以转录和长期表达外源性免疫球蛋白基因的新方法。由于体内合成和分泌的转基因免疫球蛋白对宿主具有免疫原性，并且可以对免疫球蛋白基因进行改造以编码异源表位，配体或受体，因此体细胞转基因为开发基于DNA的免疫新策略提供了独特的功能和基因疗法。

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《Gene Therapy and Molecular Biology》 |1998年第2期|共10页
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Dr. Maurizio; Zanetti;
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中图分类基础医学;
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1. Transgene activity following somatic transgenesis in Nile tilapia Oreochromis niloticus. [J] . Brooks C, Hwang G, Maclean N Journal of Fish Biology . 2007,第Suppla2期

机译：尼罗罗非鱼Oreochromis niloticus经体细胞转基因后的转基因活性。
2. Activation of CD4 T cells by somatic transgenesis induces generalized immunity of uncommitted T cells and immunologic memory. [J] . Gerloni M, Miner KT, Xiong S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第7期

机译：通过体细胞转基因激活CD4 T细胞可诱导未定型T细胞的普遍免疫力和免疫记忆。
3. Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells [J] . Ulf Klein, Klaus Rajewsky, Ralf Küppers The Journal of Experomental Medicine . 1998,第9期

机译：表达CD27细胞表面抗原的人免疫球蛋白（Ig）M + IgD +外周血B细胞携带体细胞突变的可变区基因：CD27作为体细胞突变（记忆）B细胞的通用标记
4. SOMATIC MUTATIONS CREATE POTENTIAL N-GLYCOSYLATION SITES IN THE IMMUNOGLOBULIN LIGHT CHAIN VARIABLE REGIONS IN PRIMARY AMYLOIDOSIS [C] . T. Prokaeva, B Spencer, G Doros, International Symposium on Amyloidosis . 2008

机译：体细胞突变在原发性淀粉样蛋白病中产生免疫球蛋白轻链可变区中的潜在的N-糖基化位点
5. Targeting of somatic hypermutation to immunoglobulin genes . [D] . Tanaka, Atsushi. 2009

机译：针对体细胞高突变的免疫球蛋白基因。
6. Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells [O] . Ulf Klein, Klaus Rajewsky, Ralf Küppers 1998

机译：表达CD27细胞表面抗原的人免疫球蛋白（Ig）M + IgD +外周血B细胞携带体细胞突变可变区基因：CD27作为体细胞突变（记忆）B细胞的通用标记
7. Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells [O] . Klein, Ulf, Rajewsky, Klaus, Küppers, Ralf 1998

机译：表达CD27细胞表面抗原的人免疫球蛋白（Ig）M + IgD +外周血B细胞携带体细胞突变的可变区基因：CD27作为体细胞突变（记忆）B细胞的通用标记
8. Somatic Diversification of the Chicken Immunoglobulin Light Chain Gene is limited to the Rearranged Variable Gene Segment [R] . Thompson, C. B., Neiman, P. E. 1987

机译：鸡免疫球蛋白轻链基因的体细胞多样化局限于重排的可变基因片段

Somatic transgenesis by immunoglobulin genes

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