DNA methyltransferase: a downstream effector of oncogenic programs; implications for therapy.

Dr. Moshe Szyf

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DNA methyltransferase: a downstream effector of oncogenic programs; implications for therapy.

机译：DNA甲基转移酶：致癌程序的下游效应子;对治疗的意义。

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DNA MeTase is an attractive anticancer target. A molecular analysis of its regulation suggests that it is a downstream effector of many oncogenic pathways and that its down modulation can inhibit tumor growth. It is possible that DNA MeTase inhibitor will be effective in a broad spectrum of cancers because it lies downstream to nodal cellular checkpoints that could be activated by multiple ways. An important challenge is to design novel inhibitors of DNA MeTase that are highly specific. Such inhibitors are potentially important pharmacological agents with wide therapeutic applications.

机译：DNA MeTase是一种有吸引力的抗癌靶标。对其调节的分子分析表明，它是许多致癌途径的下游效应子，并且其下调可以抑制肿瘤的生长。 DNA MeTase抑制剂可能在广泛的癌症中有效，因为它位于可通过多种方式激活的淋巴结细胞检查点的下游。一个重要的挑战是设计高度特异性的新型DNA MeTase抑制剂。这类抑制剂是潜在的重要药物，具有广泛的治疗应用。

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《Gene Therapy and Molecular Biology》 |1998年第2期|共13页
作者
Dr. Moshe Szyf;
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中图分类基础医学;
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机译：PiR-823通过DNA甲基转移酶3b通过DNA甲基化诱导证明食管鳞状细胞癌中的肿瘤致癌活性
2. Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor [J] . Irah King, Jeffrey J.Hayes Chemtracts . 2003,第13期

机译：甲基转移酶招募和靶基因启动子的DNA超甲基化的致癌转录因子。
3. DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras [J] . Kenzo Soejima, Weizhao Fang, Barrett J Rollins Oncogene . 2003,第30期

机译：DNA甲基转移酶3b有助于SV40T抗原和激活的Ras诱导的致癌转化
4. Characterization of Recombinant Maintenance DNA Methyltransferase (Dnmt1) and Application to DNA Methylation Analysis [C] . Ryota Yoshikawa, Yasuhiro Iida Pacific Rim Meeting on Electrochemical and Solid-State Science . 2020

机译：重组维持DNA甲基转移酶（DNMT1）的表征及其在DNA甲基化分析中的应用
5. Structural and functional implications of DNA delivery vehicle formulation design for targeted cancer gene therapy. [D] . Millili, Peter G. 2010

机译：DNA递送载体制剂设计对靶向癌症基因治疗的结构和功能意义。
6. The amino acid sequence of the CCGG recognizing DNA methyltransferase M.BsuFI: implications for the analysis of sequence recognition by cytosine DNA methyltransferases. [O] . J Walter, M Noyer-Weidner, T A Trautner 1990

机译：CCGG识别DNA甲基转移酶M.BsuFI的氨基酸序列：对胞嘧啶DNA甲基转移酶识别序列的意义。
7. DNA Methyltransferase Is a Downstream Effector of Cellular Transformation Triggered by Simian Virus 40 Large T Antigen [O] . Andrew Slack, Nadia Cervoni, Marc Pinard, 1999

机译：DNA甲基转移酶是由Simian病毒40大T抗原引发的细胞转化的下游效应器

DNA methyltransferase: a downstream effector of oncogenic programs; implications for therapy.

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