Mechanisms involved in regulation of the estrogen-responsive pS2 gene

Dr.; Ann M. Nardulli

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Mechanisms involved in regulation of the estrogen-responsive pS2 gene

机译：调节雌激素反应性pS2基因的机制

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Estrogen is a hormone of critical importance in the development and maintenance of normal reproductive tissues and has been implicated in initiation of mammary carcinogenesis. Estrogen's actions are mediated through an intracellular estrogen receptor (ER), which interacts with estrogen response elements (EREs) to bring about changes in transcription of estrogen-responsive genes. Although it is clear that the ER-ERE interaction is a critical link in the chain of events that lead to transcription activation, the mechanisms by which transcriptional changes occur remain unclear. We present evidence that ERE sequence and ligand act as allosteric modulators of ER conformation and that these conformational changes most likely play a role in regulating transcription of estrogen-responsive genes.

机译：雌激素是在正常生殖组织的发育和维持中至关重要的激素，并已与乳癌的发生有关。雌激素的作用是通过细胞内雌激素受体（ER）介导的，该受体与雌激素反应元件（ERE）相互作用以引起雌激素反应基因转录的变化。尽管很明显，ER-ERE相互作用是导致转录激活的事件链中的关键环节，但转录变化发生的机制仍不清楚。我们目前的证据，ERE序列和配体充当ER构象的变构调节剂，并且这些构象变化最有可能在调节雌激素响应基因的转录中发挥作用。

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《Gene Therapy and Molecular Biology》 |1999年第3期|共9页
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Dr.; Ann M. Nardulli;
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1. pS2 Gene Expression in HepG2 cells: Complex Regulation through Crosstalk between the Estrogen Receptor alpha, an Estrogen-Responsive Element, and the Activator Protein 1 Response Element. [J] . Barkhem T, Haldosen LA, Gustafsson JA, Molecular pharmacology. . 2002,第6期

机译：pS2基因在HepG2细胞中的表达：雌激素受体α，雌激素响应元件和激活蛋白1响应元件之间通过串扰进行复杂调控。
2. Regulation of the estrogen-responsive pS2 gene in MCF-7 human breast cancer cells. [J] . Kim J, Petz LN, Ziegler YS, The Journal of Steroid Biochemistry and Molecular Biology . 2000,第4期

机译：MCF-7人乳腺癌细胞中雌激素反应性pS2基因的调节。
3. Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes. [J] . Barkhem T, Andersson Ross C, Hoglund M, The Journal of Steroid Biochemistry and Molecular Biology . 1997,第1期

机译：他莫昔芬和雷洛昔芬在HepG2细胞中的“雌激素性”特征：ERE调控的报告载体对基因表达的调控与内源性SHBG和PS2基因的调控。
4. Mechanisms Involved in the Regulation of Free Radial Generation from Neutrophils [C] . Prashant Sharma, Madhu Dikshit Annual Conference of the Indian Pharmacological Society on "Chemical and Biological Warfare" . 2004

机译：涉及中性粒细胞的自由基产生的机制
5. Molecular mechanisms involved in transcription regulation of protein-encoding genes. [D] . Yuan, Wuchao. 1996

机译：参与蛋白质编码基因转录调控的分子机制。
6. Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. [O] . M Berry, A M Nunez, P Chambon 1989

机译：人pS2基因的雌激素反应元件是不完全回文序列。
7. Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. [O] . Berry, M, Nunez, A M, Chambon, P 1989

机译：人pS2基因的雌激素反应元件是不完全回文序列。
8. Regulation of Estrogen-Responsive Gene Expression and Tumor Suppression by Transcriptional Cofactors [R] . Xiao, H. 2005

机译：转录辅助因子调节雌激素反应基因表达和抑制肿瘤

Mechanisms involved in regulation of the estrogen-responsive pS2 gene

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