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Crosstalk between intra- and extracellular factors inthe development of prolactinomas in the anteriorpituitary

机译：垂体前叶泌乳素瘤发展过程中细胞内和细胞外因素之间的串扰

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摘要

Prolactinomas are non invasive neoplasms resulting from an abnormal proliferation of the lactotroph cells in the anterior pituitary. Although prolactinomas have clearly been shown to be monoclonal tumors, the seek for the initial causal mutation has not been successful yet. In parallel to the recent advances made in the mutation analyses, this review aims at presenting the main extracellular factors, such as hypothalamic factors, estrogens, growth factors and cytokines, that could participate to the overproliferation of the lactotroph cells. In addition to their role in the development and maintenance of prolactinomas, it is proposed that the initial causal mutation could take place in the transduction pathways of such extracellular factors. Taking in account the complex regulation of the anterior pituitary could help in designing more specific and efficient treatments, especially for patients resistant to the most commonly used bromocriptine therapy.
机译：催乳素瘤是非垂体瘤，是由于垂体前叶的营养缺陷型细胞异常增殖所致。尽管泌乳素瘤已明确显示为单克隆肿瘤，但寻找初始因果突变尚未成功。与突变分析的最新进展同时进行的是，本综述旨在介绍可能参与乳化营养细胞过度增殖的主要细胞外因子，例如下丘脑因子，雌激素，生长因子和细胞因子。除了它们在泌乳素瘤的发展和维持中的作用外，有人提出最初的因果突变可能发生在此类细胞外因子的转导途径中。考虑到垂体前叶的复杂调节可能有助于设计更具体和有效的治疗方法，特别是对于对最常用的溴隐亭疗法有抵抗力的患者。

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