Gene therapy targeting p53

Dr.; John Nemunaitis

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Gene therapy targeting p53

机译：靶向p53的基因疗法

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The product of the p53 gene plays a critical role in the regulation of cell growth. Mutations of this gene are associated with transformation to a malignant phenotype. Correction of the gene defect through transfer of a wildtype p53 gene into malignant cells, or targeting malignant cells with oncolytic viruses (ONYX-015) genetically engineered to proliferate in cells containing mutant genes has been identified as a therapeutic approach by preclinical assessment. Initial clinical trials have confirmed functional activity and expression of the transgene product in Adp53-injected malignant tissue and tumor specific viral proliferation have been observed in patients receiving intratumoral injection of ONYX-015.

机译：p53基因的产物在调节细胞生长中起关键作用。该基因的突变与转化为恶性表型有关。通过临床前评估，通过将野生型p53基因转移到恶性细胞或用经基因工程改造以在含有突变基因的细胞中增殖的溶瘤病毒（ONYX-015）靶向恶性细胞来纠正基因缺陷已被确认为治疗方法。最初的临床试验已经证实，在接受瘤内注射ONYX-015的患者中观察到功能活性和转基因产物在Adp53注射的恶性组织中的表达，并且观察到肿瘤特异性病毒增殖。

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《Gene Therapy and Molecular Biology》 |1999年第3期|共10页
作者
Dr.; John Nemunaitis;
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中图分类基础医学;
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1. Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma [J] . Brook Lemlem, Palade Patricia, Maatough Anas, Journal of cellular biochemistry. . 2019,第1期

机译：无毛调节P53靶基因以施加胶质母细胞瘤中的肿瘤抑制功能，可释放p53靶基因在胶质母细胞瘤中施加肿瘤抑制功能
2. p53 activated by AND gate genetic circuit under radiation and hypoxia for targeted cancer gene therapy [J] . Ding Miao, Li Rong, He Rong, Cancer science. . 2015,第9期

机译：放射线和缺氧条件下，AND门遗传电路激活p53用于靶向癌症基因治疗
3. p53 activated by AND gate genetic circuit under radiation and hypoxia for targeted cancer gene therapy [J] . Miao Ding, Qijian Yi, Rong He, Cancer science. . 2015,第9期

机译：辐射和缺氧条件下，AND门遗传电路激活p53进行靶向癌基因治疗
4. New p53-targeted Cancer Therapies Combined with Gene or ChemicalChaperone Therapy [C] . The 3rd Asian congress on hyperthermic oncology and the 9th Chineses symposium on hyperthermic oncology . 2002

机译：结合基因或化学伴侣疗法的新型针对p53的癌症疗法
5. The Novel p53 Target Gene STK17A: Implications for Cancer Therapy. [D] . Mao, Pingping. 2015

机译：新型p53靶基因STK17A：对癌症治疗的意义。
6. Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53 [O] . Heejei Yoon, Sandya Liyanarachchi, Fred A. Wright, 2007

机译：具有不同TP53基因剂量的等基因细胞的基因表达谱分析揭示了受TP53剂量影响的众多基因，并将CSPG2鉴定为p53的直接靶标
7. Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53 [O] . Yoon, Heejei, Liyanarachchi, Sandya, Wright, Fred A., 2002

机译：具有不同TP53基因剂量的等基因细胞的基因表达谱分析揭示了受TP53剂量影响的众多基因，并将CSPG2鉴定为p53的直接靶标

Gene therapy targeting p53

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