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首页> 外文期刊>Gene Therapy and Molecular Biology >Intramuscular injection of plasmid DNA encoding intracellular or secreted glutamic acid decarboxylase causes decreased insulitis in the non- obese diabetic mouse
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Intramuscular injection of plasmid DNA encoding intracellular or secreted glutamic acid decarboxylase causes decreased insulitis in the non- obese diabetic mouse

机译：肌内注射编码细胞内或分泌的谷氨酸脱羧酶的质粒DNA会导致非肥胖糖尿病小鼠的胰岛炎减少

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摘要

Our goal is to determine whether gene vaccination can be used for the treatment of insulin- dependent diabetes mellitus (IDDM), an autoimmune disease. In this work, weanling non-obese diabetic (NOD) mice, an animal model system for the study of IDDM, received intramuscular injections of “naked” plasmid DNA encoding either intracellular or secreted human glutamic acid decarboxylase (GAD), one of the major autoantigens recognized during the onset of IDDM. Seven weeks later, each pancreas was scored for insulitis, an inflammation indicative of the disease. Mice treated with either type of gad gene-carrying plasmid showed a significant decrease in the severity of insulitis when compared to controls. These results suggest that vaccination using autoantigen- encoding genes may provide a means of treating IDDM.
机译：我们的目标是确定基因疫苗是否可用于治疗自身免疫性疾病胰岛素依赖型糖尿病（IDDM）。在这项工作中，断奶的非肥胖糖尿病（NOD）小鼠（一种研究IDDM的动物模型系统）接受了肌肉内注射的“裸”质粒DNA的编码，该DNA编码细胞内或分泌的人谷氨酸脱羧酶（GAD），这是主要的一种在IDDM发作期间识别的自身抗原。七个星期后，对每个胰腺进行胰岛炎评分，炎症是一种疾病的征兆。与对照组相比，用两种类型的带有gad基因的携带质粒处理的小鼠均显示出炎性肠炎的严重程度显着降低。这些结果表明，使用自身抗原编码基因的疫苗接种可能提供治疗IDDM的方法。

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