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Engineered Smart Biomaterials for Gene Delivery

机译：设计用于基因传递的智能生物材料

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The delivery technology of gene into cells has been increasingly paid attention for gene therapy and the generation of genetically engineered cells. If it is possible to artificially introduce exogenous genetic materials into cells at a high transfection efficiency by a delivery technology, the technology will give academically, clinically, and practically great impacts to gene therapy, cell and molecular biology or pharmaceutical and food industries for bio-productions. The major aim of gene therapy is to effectively deliver the genetic materials into cells, genetically modifying and repairing cell functions, which may induce therapeutic healing of disease conditions. The genetic material involves DNA, RNA, antisense, DNA decoy, and ribozyme, and it is expected that their appropriate transfection allows disease cells to turn to a good direction of recovery. The genetic manipulation often manifests the mechanisms of intracellular machineries of gene and protein, while it may play an important role in making clear the appropriate genes associated with various diseases. Based on the basic and scientific knowledge, the delivery technology of gene is applicable to produce various proteins pharmaceutically valuable, e.g. cytokines, growth factors, and antibodies as well as seeds strong against harmful insects and cold weather damage. In other words, the cells genetically innovated work as the microfactory to produce valuable pharmaceutical and food products. This review provides a critical view of different approaches of gene therapy with a major focus on smart biomaterials transfection agent technologies to control the in vitro and in vivo localization and function of administered genes.
机译：基因向细胞中的传递技术已经越来越受到基因治疗和基因工程细胞的关注。如果可以通过传递技术将外源遗传物质以高转染效率人工引入细胞，则该技术将对基因治疗，细胞和分子生物学或生物制药和食品工业产生重大的学术，临床和实践影响生产。基因治疗的主要目的是将遗传物质有效地传递到细胞中，进行遗传修饰和修复细胞功能，从而诱导疾病的治疗性愈合。遗传物质涉及DNA，RNA，反义，DNA诱饵和核酶，预期它们的适当转染可使疾病细胞转向良好的恢复方向。遗传操纵常表现出基因和蛋白质在细胞内机制的机制，同时在阐明与各种疾病有关的适当基因方面可能起重要作用。基于基础和科学知识，基因的递送技术可用于产生药学上有价值的各种蛋白质，例如蛋白质。细胞因子，生长因子和抗体，以及对有害昆虫和寒冷天气造成伤害的种子均很强。换句话说，经过基因改造的细胞可以作为生产有价值的药品和食品的微型工厂。这篇综述提供了对基因治疗不同方法的批判性观点，主要侧重于智能生物材料转染剂技术，以控制所施用基因的体外和体内定位以及功能。

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