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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >The Effects of Radix Astragali Water Abstract on Energy Metabolism in Rat Yang-Deficiency Cold Syndrome Model through PPAR Signaling Pathway
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The Effects of Radix Astragali Water Abstract on Energy Metabolism in Rat Yang-Deficiency Cold Syndrome Model through PPAR Signaling Pathway

机译：黄芪水通过PPAR信号通路对阳虚寒证模型大鼠能量代谢的影响

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摘要

Radix Astragali (RA) herb with warm property and significant “tonifying qi” effects is indicated for the syndrome of internal cold due to Yang deficiency. The purpose of this research was to explore effects of Radix Astragali (RA) through PPAR signaling pathway on gene expression profiles related to energy metabolism in rats with the Yang-deficiency cold (YDC) syndrome, for identifying the pathological mechanism of Yang-deficiency cold (YDC) syndrome and the effects mechanism of RA. The results indicated that RA could significantly increase body weight (BM), cold and heat tendency (CT), overall temperature (OT), rectum temperature (RT), toe temperature (TT), energy intake (EI), and V(O2)/V(CO2) ratio (which indicates basal metabolism, BM) (P<0.05), enhancing the depressed metabolic function in YDC syndrome model rat. Our data also indicated differentially expressed genes (DEGs) related to energy metabolism involving lipids, carbohydrates, and amino acids metabolic process; the expression of CPT-1 and FABP4 (ap2) was improved; PPAR, Glycolysis, Wnt, cAMP, MAPK, AMPK, and fatty acid degradation signaling pathway may be related to energy metabolism. However, the Chinese herbal medicine RA plays a certain role in promoting the metabolism of substances and energy in rats by its warming and beneficial effect. Our results suggest that the mechanism underlying the function of RA may take effect through the regulation of PPAR signaling pathway and related gene expression. Lipids, carbohydrates, and amino acids metabolic process may be affected to adjust the reduced metabolic function in the model animals. In general, results indicate that RA could promote energy metabolism in rats with the YDC syndrome via PPAR signaling pathway regulating the expression of CPT-1 and FABP4 (ap2), which reflected the warm and qi tonifying properties of RA.
机译：黄芪具有保暖性和显着的“补气”作用，可用于阳虚引起的内感综合症。这项研究的目的是探讨黄芪通过PPAR信号通路对阳虚感冒（YDC）综合征大鼠能量代谢相关基因表达谱的影响，以确定阳虚感冒的病理机制。 （YDC）综合征和RA的作用机制。结果表明RA可以显着增加体重（BM），冷热趋势（CT），总体温度（OT），直肠温度（RT），脚趾温度（TT），能量摄入（EI）和V（O2） ）/ V（CO2）比（表示基础代谢，BM）（P <0.05），可增强YDC综合征模型大鼠的抑郁代谢功能。我们的数据还表明与能量代谢有关的差异表达基因（DEG），涉及脂质，碳水化合物和氨基酸代谢过程。 CPT-1和FABP4（ap2）的表达得到改善; PPAR，糖酵解，Wnt，cAMP，MAPK，AMPK和脂肪酸降解信号通路可能与能量代谢有关。然而，中草药RA具有变暖和有益的作用，在促进大鼠体内物质代谢和能量代谢方面具有一定作用。我们的结果表明，RA功能的潜在机制可能通过调节PPAR信号通路和相关基因表达来发挥作用。脂质，碳水化合物和氨基酸的代谢过程可能会受到影响，以调节模型动物代谢功能的降低。总体而言，结果表明RA可以通过PPAR信号通路调节CPT-1和FABP4（ap2）的表达来促进YDC综合征大鼠的能量代谢，这反映了RA的温暖和补气特性。

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