...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes and Nutrition >Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome
【24h】

Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome

机译：铜和铁缺乏相关血脂异常的分子基础：大鼠肠道转录组的微阵列分析。

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

As essential cofactor in many proteins and redox enzymes, copper and iron are involved in a wide range of biological processes. Mild dietary deficiency of metals represents an underestimated problem for human health, because it does not cause clear signs and clinical symptoms, but it is associated to long-term deleterious effects in cardiovascular system and alterations in lipid metabolism. The aim of this work was to study the biological processes significantly affected by mild dietary deficiency of both metals in rat intestine, in order to better understand the molecular bases of the systemic metabolic alterations, as hypercholesterolemia and hypertriglyceridemia observed in copper-deficient rats. A gene-microarray differential analysis was carried out on the intestinal transcriptome of copper- and iron-deficient rats, thus highlighting the biological processes significantly modulated by the dietary restrictions. The gene array analysis showed a down-regulation of genes involved in mitochondrial and peroxisomal fatty acids beta-oxidation and an up-regulation of genes involved in plasmatic cholesterol transport (apoprotein E and lecithin:cholesterol acyltransferase) in copper deficiency. Furthermore, a severe down-regulation of ApoH was pointed out in iron-deficient animals.
机译：作为许多蛋白质和氧化还原酶中必不可少的辅助因子，铜和铁参与了广泛的生物过程。饮食中金属的轻度缺乏代表了对人类健康的低估问题，因为它不会引起明显的体征和临床症状，但与心血管系统的长期有害作用和脂质代谢的改变有关。这项工作的目的是研究受大鼠肠道中两种金属的轻度饮食缺乏严重影响的生物学过程，以便更好地了解全身代谢改变的分子基础，如在缺铜大鼠中观察到的高胆固醇血症和高甘油三酯血症。对缺铜和缺铁大鼠的肠道转录组进行了基因-微阵列差异分析，从而突出了受饮食限制显着调节的生物学过程。基因阵列分析显示，铜缺乏时，线粒体和过氧化物酶体脂肪酸β-氧化涉及的基因下调，血浆胆固醇转运（脱辅基蛋白E和卵磷脂：胆固醇酰基转移酶）涉及的基因上调。此外，指出缺铁动物中ApoH的严重下调。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号