...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes and Nutrition >APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake
【24h】

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

机译：在为期三个月的旨在减少脂肪摄入的主要干预研究中，APOB-516 T等位基因纯合受试者对饮食变化无反应

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dietary guidelines aim to control fat intake and reduce cardiovascular risk but an important interindividual variability occurs among subjects. The objective was to investigate whether the response of lipid and glucose homeostasis parameters after a three-month diet aimed at reducing cardiovascular risk could be modulated by the ?516C/T polymorphism in the apolipoprotein B gene (APOB). Middle-aged men (n?=?69) and women (n?=?100) with moderate cardiovascular disease risk were advised to reduce total energy and fat intakes and replace saturated dietary fat by monounsaturated and polyunsaturated fat. Subjects were genotyped for APOB-516C/T polymorphism. At the entry and at the end of the three-month period, fasting and postprandial plasma lipid analyses were performed. At entry, subjects homozygous for the APOB-516 T allele exhibited significantly lower fasting plasma concentrations of apolipoprotein B 48, triglycerides and triglyceride-rich lipoproteins-triglycerides compared to C carrier subjects. After the diet period, while C carrier subjects presented a clear improvement of most biological parameters, paradoxically T/T subjects did not modify them. In addition, the apoB 48 postprandial response after a standardized mixed test meal was not improved in T/T subjects after the three-month diet, contrary to C allele carriers. Even though their phenotype at entry does not show any significant increase of risk factors when compared to other groups, subjects homozygous for the APOB-516 T allele are unresponsive to a healthy diet that improves cardiovascular risk status in the whole population.
机译：饮食指南旨在控制脂肪摄入并降低心血管风险，但受试者之间存在重要的个体差异。目的是研究载脂蛋白B基因（APOB）的？516C / T多态性能否调节三个月饮食以降低心血管风险后对脂质和葡萄糖稳态参数的反应。建议中度心血管疾病风险的中年男性（n = 69）和女性（n = 100）减少总能量和脂肪摄入，并用单不饱和脂肪和多不饱和脂肪代替饱和饮食脂肪。对受试者进行APOB-516C / T多态性的基因分型。在三个月的进入期和结束时，进行禁食和餐后血浆脂质分析。在进入时，与C携带者相比，纯合APOB-516 T等位基因的受试者表现出空腹血浆载脂蛋白B 48，甘油三酸酯和富含甘油三酸酯的脂蛋白-甘油三酸酯的空腹血浆浓度显着降低。饮食期后，尽管C携带者受试者对大多数生物学参数都有明显的改善，但自相矛盾的是T / T受试者并未对其进行修改。另外，与C等位基因携带者相反，在三个月的饮食之后，T / T受试者在标准化混合测试餐后的apoB 48餐后反应没有改善。尽管与其他组相比，它们的进入表型没有显示任何危险因素显着增加，但纯合APOB-516 T等位基因的受试者对健康饮食无反应，健康饮食改善了整个人群的心血管风险。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号