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首页> 外文期刊>Genes and Nutrition >Chemopreventive potential of curcumin in prostate cancer
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Chemopreventive potential of curcumin in prostate cancer

机译：姜黄素在前列腺癌中的化学预防潜力

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The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits therapeutic promise for prostate cancer. In fact, it interferes with prostate cancer proliferation and metastasis development through the down-regulation of androgen receptor and epidermal growth factor receptor, but also through the induction of cell cycle arrest. It regulates the inflammatory response through the inhibition of pro-inflammatory mediators and the NF-κB signaling pathway. These results are consistent with this compound’s ability to up-induce pro-apoptotic proteins and to down-regulate the anti-apoptotic counterparts. Alone or in combination with TRAIL-mediated immunotherapy or radiotherapy, curcumin is also reported to be a good inducer of prostate cancer cell death by apoptosis. Curcumin appears thus as a non-toxic alternative for prostate cancer prevention, treatment or co-treatment.
机译：前列腺癌发生的长潜伏期和高发生率提供了干预化学预防以预防或根除前列腺恶性肿瘤的机会。我们在这里概述姜黄素（二氟甲酰甲烷）的化学预防潜力，这是一种众所周知的天然化合物，对前列腺癌具有治疗前景。实际上，它通过雄激素受体和表皮生长因子受体的下调，以及通过诱导细胞周期停滞来干扰前列腺癌的增殖和转移发展。它通过抑制促炎介质和NF-κB信号通路来调节炎症反应。这些结果与该化合物上调促凋亡蛋白和下调抗凋亡蛋白的能力一致。姜黄素单独或与TRAIL介导的免疫疗法或放射疗法结合使用，据报道也是凋亡诱导前列腺癌细胞死亡的良好诱因。因此姜黄素似乎是预防，治疗或联合治疗前列腺癌的一种无毒替代品。

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