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首页> 外文期刊>Genes and Nutrition >Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation
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Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation

机译：表达阵列数据的生物信息学研究，以鉴定可能由DNA甲基化调节的营养调控基因

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摘要

DNA methylation occurs at CpG dinucleotide sites within the genome and is recognised as one of the mechanisms involved in regulation of gene expression. CpG sites are relatively underrepresented in the mammalian genome, but occur densely in regions called CpG islands (CGIs). CGIs located in the promoters of genes inhibit transcription when methylated by impeding transcription factor binding. Due to the malleable nature of DNA methylation, environmental factors are able to influence promoter CGI methylation patterns and thus influence gene expression. Recent studies have provided evidence that nutrition (and other environmental exposures) can cause altered CGI methylation but, with a few exceptions, the genes influenced by these exposures remain largely unknown. Here we describe a novel bioinformatics approach for the analysis of gene expression microarray data designed to identify regulatory sites within promoters of differentially expressed genes that may be influenced by changes in DNA methylation.
机译：DNA甲基化发生在基因组内的CpG二核苷酸位点，被认为是调节基因表达的机制之一。 CpG位点在哺乳动物基因组中相对不足，但在称为CpG岛（CGI）的区域中密集地出现。当通过阻碍转录因子结合而被甲基化时，位于基因启动子中的CGI会抑制转录。由于DNA甲基化的可塑性，环境因素能够影响启动子CGI甲基化模式，从而影响基因表达。最近的研究提供了证据，表明营养（和其他环境暴露）可导致CGI甲基化改变，但除少数例外，受这些暴露影响的基因仍然未知。在这里，我们描述了一种新的生物信息学方法，用于分析基因表达微阵列数据，旨在识别差异表达基因的启动子内的调控位点，该位点可能受DNA甲基化变化的影响。

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