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首页> 外文期刊>Genes and Nutrition >Gene expression profiles in human HepG2 cells treated with extracts of the Tamarindus indica fruit pulp
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Gene expression profiles in human HepG2 cells treated with extracts of the Tamarindus indica fruit pulp

机译：罗望子Ta果肉提取物处理人HepG2细胞的基因表达谱

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Tamarindus indicaL. (T. indica) or locally known as asam jawa belongs to the family of Leguminosae. The fruit pulp had been reported to have antioxidant activities and possess hypolipidaemic effects. In this study, we attempted to investigate the gene expression patterns in human hepatoma HepG2 cell line in response to treatment with low concentration of the fruit pulp extracts. Microarray analysis using Affymetrix Human Genome 1.0 S.T arrays was used in the study. Microarray data were validated using semi-quantitative RT–PCR and real-time RT–PCR. Amongst the significantly up-regulated genes were those that code for the metallothioneins (MT1M, MT1F, MT1X) and glutathione S-transferases (GSTA1, GSTA2, GST02) that are involved in stress response. APOA4, APOA5, ABCG5 and MTTP genes were also significantly regulated that could be linked to hypolipidaemic activities of the T. indica fruit pulp.
机译：罗望子果。 （T. indica）或当地称为asam limba属于豆科。据报道，果肉具有抗氧化作用并具有降血脂作用。在这项研究中，我们试图研究低浓度果肉提取物对人肝癌HepG2细胞系中基因表达模式的影响。在这项研究中使用了使用Affymetrix Human Genome 1.0 S.T阵列进行的微阵列分析。使用半定量RT-PCR和实时RT-PCR验证了微阵列数据。其中显着上调的基因是编码与应激反应有关的金属硫蛋白（MT1M，MT1F，MT1X）和谷胱甘肽S-转移酶（GSTA1，GSTA2，GST02）的基因。还显着调节了APOA4，APOA5，ABCG5和MTTP基因，这可能与in果果肉的降血脂活性有关。

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