Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

Xiaobo Zhou; Weiliang Qiu; J. Fah Sathirapongsasuti; Michael H. Cho; John D. Mancini; Taotao Lao; Derek M. Thibault; Augusto A. Litonjua; Per S. Bakke; Amund Gulsvik; David A. Lomas; Terri H. Beaty; Craig P. Hersh; Christopher Anderson; Ute Geigenmuller; Benjamin A. Raby; Stephen I. Rennard; Mark A. Perrella; Augustine M.K. Choi; John Quackenbush; Edwin K. Silverman

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Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

机译：基因表达分析揭示了人类支气管上皮细胞中的新型刺猬相互作用蛋白（HHIP）作用

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Hedgehoginteractingprotein(emHHIP/em)wasimplicatedinchronicobstructivepulmonarydisease(COPD)bygenome-wideassociationstudies(GWAS).However,itremainsunclearhowemHHIP/emcontributestoCOPDpathogenesis.ToidentifygenesregulatedbyHHIP,weperformedgeneexpressionmicroarrayanalysisinahumanbronchialepithelialcellline(Beas-2B)stablyinfectedwithemHHIP/emshRNAs.emHHIP/emsilencingledtodifferentialexpressionof296genes;enrichmentforvariantsnominallyassociatedwithCOPDwasfound.Eighteenofthedifferentiallyexpressedgeneswerevalidatedbyreal-timePCRinBeas-2Bcells.Sevenof11validatedgenestestedinhumanCOPDandcontrollungtissuesdemonstratedsignificantgeneexpressiondifferences.Functionalannotationindicatedenrichmentforextracellularmatrixandcellgrowthgenes.NetworkmodelingdemonstratedthattheextracellularmatrixandcellproliferationgenesinfluencedbyHHIPtendedtobeinterconnected.Thus,weidentifiedpotentialHHIPtargetsinhumanbronchialepithelialcellsthatmaycontributetoCOPDpathogenesis./p/div

机译：整个基因组关联研究（GWAS）证实了刺猬相互作用蛋白（ HHIP ）简化了慢性阻塞性肺疾病（COPD）。然而，仍然清楚的是 HHIP 贡献测试COPD的发病机理。。EM>的shRNA的 HHIP silencingledtodifferentialexpressionof296genes; enrichmentforvariantsnominallyassociatedwithCOPDwasfound.Eighteenofthedifferentiallyexpressedgeneswerevalidatedbyreal-timePCRinBeas-2Bcells.Sevenof11validatedgenestestedinhumanCOPDandcontrollungtissuesdemonstratedsignificantgeneexpressiondifferences.Functionalannotationindicatedenrichmentforextracellularmatrixandcellgrowthgenes.NetworkmodelingdemonstratedthattheextracellularmatrixandcellproliferationgenesinfluencedbyHHIPtendedtobeinterconnected.Thus，weidentifiedpotentialHHIPtargetsinhumanbronchialepithelialcellsthatmaycontributetoCOPDpathogenesis 展开▼

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《Genomics》 |2013年第5期|共页

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Xiaobo Zhou; Weiliang Qiu; J. Fah Sathirapongsasuti; Michael H. Cho; John D. Mancini; Taotao Lao; Derek M. Thibault; Augusto A. Litonjua; Per S. Bakke; Amund Gulsvik; David A. Lomas; Terri H. Beaty; Craig P. Hersh; Christopher Anderson; Ute Geigenmuller; Benjamin A. Raby; Stephen I. Rennard; Mark A. Perrella; Augustine M.K. Choi; John Quackenbush; Edwin K. Silverman;
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中图分类医学遗传学;

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1. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells [J] . ZhouX., QiuW., SathirapongsasutiJ.F., Genomics . 2013,第5期

机译：基因表达分析揭示了人类支气管上皮细胞中的新型刺猬相互作用蛋白（HHIP）作用

2. Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells [J] . Li Peichao, Zhang Xiaoru, Murphy Anthony J., Carcinogenesis . 2021,第1期

机译：刺猬相互作用蛋白（HIPH）的下调有助于六价铬诱导人支气管上皮细胞的恶性转化

3. AT(2)R deficiency mediated podocyte loss via activation of ectopic hedgehog interacting protein (Hhip) gene expression [J] . Liao Min-Chun, Zhao Xin-Ping, Chang Shiao-Ying, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2017,第3期

机译：（2）R缺乏介导的泛键细胞损失通过异位刺猬相互作用蛋白（HHIP）基因表达

4. Effects of stearate on mRNA expression of genes associated with milk fat and protein biosynthesis in bovine mammary epithelial cells [C] . L.Z.Qi, S.M.Yan, R.Sheng, 3rd international symposium on dairy cow nutrition and milk quality proceedings . 2013

机译：硬脂酸酯对牛乳上皮细胞乳脂相关基因mRNA表达及蛋白质合成的影响

5. Gene expression analysis of human non -small cell lung cancer subtypes, adenocarcinoma and squamous cell carcinoma, and mouse lung epithelial cell lines: Implications in lung tumorigenesis [D] . Silvers, Amy Lynn. 2002

机译：人类非小细胞肺癌亚型，腺癌和鳞状细胞癌以及小鼠肺上皮细胞系的基因表达分析：在肺肿瘤发生中的意义

6. Gene expression analysis uncovers novel Hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells [O] . Xiaobo Zhou, Weiliang Qiu, J. Fah. Sathirapongsasuti, -1

机译：基因表达分析在人支气管上皮细胞中揭开新型刺猬相互作用蛋白（Hhip）的作用

7. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells [O] . Zhou Xiaobo, Qiu Weiliang, Sathirapongsasuti J. Fah, 2013

机译：基因表达分析揭示了人类支气管上皮细胞中的新型刺猬相互作用蛋白（HHIP）作用

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Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

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