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首页> 外文期刊>Genome Integrity >Low levels of ATM in breast cancer patients with clinical radiosensitivity
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Low levels of ATM in breast cancer patients with clinical radiosensitivity

机译：患有临床放射敏感性的乳腺癌患者中的ATM水平较低

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Background and Purpose Adjuvant radiotherapy for cancer can result in severe adverse side effects for normal tissues. In this respect, individuals with anomalies of the ATM (ataxia telangiectasia) protein/gene are of particular interest as they may be at risk of both breast cancer and clinical radiosensitivity. The association of specific ATM gene mutations with these pathologies has been well documented, however, there is uncertainty regarding pathological thresholds for the ATM protein. Results Semi-quantitative immuno-blotting provided a reliable and reproducible method to compare levels of the ATM protein for a rare cohort of 20 cancer patients selected on the basis of their severe adverse normal tissue reactions to radiotherapy. We found that 4/12 (33%) of the breast cancer patients with severe adverse normal tissue reactions following radiotherapy had ATM protein levels Conclusions ATM mutations are generally considered low risk alleles for breast cancer and clinical radiosensitivity. From results reported here we propose a tentative ATM protein threshold of ~55% for high-risk of clinical radiosensitivity for breast cancer patients.
机译：背景和目的癌症的辅助放疗可能对正常组织产生严重的不良副作用。在这方面，具有ATM（共济失调毛细血管扩张）蛋白/基因异常的个体可能引起乳腺癌和临床放射敏感性的风险，因此特别受到关注。特定的ATM基因突变与这些病理学的关联已得到充分证明，但是，关于ATM蛋白的病理学阈值尚不确定。结果半定量免疫印迹法提供了一种可靠且可重现的方法，可以比较20例罕见癌症患者的ATM蛋白水平，这些患者是根据对放疗的严重不良正常组织反应选择的。我们发现，放疗后有严重不良正常组织反应的乳腺癌患者中，有4/12（33％）的ATM蛋白水平为高。结论ATM突变通常被认为是乳腺癌和临床放射敏感性的低风险等位基因。根据此处报道的结果，我们建议将乳腺癌患者临床放射敏感性高风险的暂定ATM蛋白阈值设为〜55％。

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