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首页> 外文期刊>Genetics and Molecular Research >IL-23 promotes osteoclastogenesis in osteoblast-osteoclast co-culture system
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IL-23 promotes osteoclastogenesis in osteoblast-osteoclast co-culture system

机译：IL-23在成骨细胞-破骨细胞共培养系统中促进破骨细胞生成

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The aim of this study was to determine the effect of IL-23 on the activity and proliferation of osteoclasts (OC) in co-culture with osteoblasts (OB). OB and OC were individually separated from the skull and femoral bone of a SD rat. OB-OC co-culture with IL-23 added was designed as the experimental group, while the OB-OC co-culture without IL-23 was the control group. In the experimental group, five different concentrations of IL-23 were added, and the cells were then cultured for 24, 48 and 72 h. For each concentration at these three time points, cell proliferation, tartrate-resistant acid phosphatase (TRAP) activity and the lacunae in the bone slices were evaluated, compared with control group at the same time points. Compared to the control group, proliferation and TRAP activity of OC were significantly increased at 24, 48 and 72 h with addition of 0.5 to 10 ng/mL IL-23 (P.
机译：这项研究的目的是确定IL-23对与成骨细胞（OB）共培养的破骨细胞（OC）活性和增殖的影响。 OB和OC分别与SD大鼠的头骨和股骨分开。将添加有IL-23的OB-OC共培养物设计为实验组，而没有IL-23的OB-OC共培养物为对照组。在实验组中，加入五种不同浓度的IL-23，然后将细胞培养24、48和72小时。对于这三个时间点的每种浓度，与相同时间点的对照组相比，评估了骨切片中的细胞增殖，抗酒石酸酸性磷酸酶（TRAP）活性和腔隙。与对照组相比，添加0.5至10 ng / mL IL-23可使OC的增殖和TRAP活性在24、48和72 h显着增加（P.

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