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首页> 外文期刊>Genetics and Molecular Research >Association between a non-synonymous HSD17B4 single nucleotide polymorphism and meat-quality traits in Berkshire pigs
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Association between a non-synonymous HSD17B4 single nucleotide polymorphism and meat-quality traits in Berkshire pigs

机译：非同义HSD17B4单核苷酸多态性与伯克希尔猪肉品质性状的关联

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摘要

Single nucleotide polymorphisms (SNPs) are useful genetic markers that allow correlation of genetic sequences with phenotypic traits. It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during β-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:128,825,976AG, c.2137AG, I690V, within the sterol carrier protein-2 domain of the HSD17B4 gene, by RNA-Seq of liver RNA. The HSD17B4 mRNA was highly expressed in the kidney and liver among various other tissues in four pig breeds, namely, Berkshire, Duroc, Landrace, and Yorkshire. The nsSNP was significantly associated with carcass weight, backfat thickness, and drip loss (P 0.05). Furthermore, HSD17B4 may play a crucial role during the early stages of myogenesis when expression of its mRNA was significantly high. In conclusion, HSD17B4 may serve as a possible regulator of muscle development, and its identification should help to select for improved economic traits of Berkshire pigs such as carcass weight, backfat thickness, and drip loss.
机译：单核苷酸多态性（SNP）是有用的遗传标记，允许遗传序列与表型性状相关。此处显示，HSD17B4是一种介导长链脂肪酸的β-氧化过程中脱氢和脱水的双功能酶，其非同义SNP（nsSNP）为chr2：128,825,976A> G，c.2137A> G，I690V，在HSD17B4基因的固醇载体蛋白2结构域中，通过肝脏RNA的RNA-Seq。 HSD17B4 mRNA在四个猪品种，即伯克希尔，杜洛克，长白和约克郡的其他各种组织中的肾脏和肝脏中高表达。 nsSNP与car体重量，后脂肪厚度和滴落损失显着相关（P <0.05）。此外，当HSD17B4的mRNA表达非常高时，它可能在成肌的早期阶段起着至关重要的作用。总之，HSD17B4可能是肌肉发育的调节剂，其鉴定应有助于选择改善伯克希尔猪的经济特性，例如car体重量，背脂肪厚度和滴水损失。

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