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MMP-9 genetic polymorphism may confer susceptibility to COPD

机译：MMP-9基因多态性可能使人患上COPD

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摘要

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% confidence intervals was applied to assess the correlation between genetic polymorphisms of MMPs and susceptibility to COPD. Twelve high-quality studies were selected for inclusion in this meta-analysis. These studies included a combined total of 1533 COPD patients and 1530 healthy controls. The result of the meta-analysis showed that MMP-9 rs3918242 C T was significantly correlated with increased susceptibility to COPD. However, MMP-1 rs1799750 1G 2G and MMP-3 rs3025058 5A 6A were not associated with COPD risk (all P 0.05). Based on our meta-analysis, MMP-9 rs3918242 C T is correlated with susceptibility to COPD, but MMP-1 rs1799750 1G 2G and MMP-3 rs3025058 5A 6A are not. These results should be further confirmed using a larger sample size.
机译：研究了三种基质金属蛋白酶（MMP）基因的遗传多态性与慢性阻塞性肺疾病（COPD）易感性之间的关系。使用严格的纳入和排除标准选择相关的病例对照研究。使用综合的Meta-analysis 2.0软件进行统计分析。应用具有95％置信区间的比值比评估MMP的遗传多态性与COPD易感性之间的相关性。选择了十二项高质量研究纳入该荟萃分析。这些研究总共包括1533名COPD患者和1530名健康对照。荟萃分析的结果表明，MMP-9 rs3918242 C> T与对COPD的敏感性增加显着相关。但是，MMP-1 rs1799750 1G> 2G和MMP-3 rs3025058 5A> 6A与COPD风险无关（所有P> 0.05）。根据我们的荟萃分析，MMP-9 rs3918242 C> T与COPD易感性相关，但MMP-1 rs1799750 1G> 2G和MMP-3 rs3025058 5A> 6A无关。使用较大的样本量应进一步确认这些结果。

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