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Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis

机译：miR-137基因多态性与精神分裂症风险的关联：一项荟萃分析

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miR-137, a brain-enriched microRNA, is involved in the control of neuronal proliferation, differentiation, and dendritic arborization, all of which are important for proper neurogenesis and relevant to schizophrenia. miR-137 is also known to regulate many genes implicated in schizophrenia risk. Although reports have associated the miR-137 polymorphism rs1625579 with this disease, their results have been inconsistent. The aim of this meta-analysis was to evaluate the relationship between rs1625579 and schizophrenia. Data were obtained from an electronic database, and pooled odds ratios (ORs) with 95% confidence intervals (95%CI) were used to test the association using the RevMan 5.3 software. Twelve case-control studies comprising 11,583 cases and 14,315 controls were included. An estimated lambda value of 0.46 was recorded, suggesting that a codominant model of inheritance was most likely. A statistically significant association was established under allelic (T vs G: OR = 1.15, 95%CI = 1.10-1.21, P vs GG: OR = 1.32, 95%CI = 1.13-1.54, P vs GG: OR = 1.14, 95%CI = 0.97-1.34, P = 0.11). This meta-analysis demonstrates that the rs1625579 miR-137 genetic variant significantly increases schizophrenia risk.
机译：miR-137是一种富含大脑的microRNA，参与神经元增殖，分化和树突状树突形成的控制，所有这些对于正常的神经发生都很重要，并且与精神分裂症有关。还已知miR-137可以调节许多与精神分裂症风险有关的基因。尽管有报道将miR-137多态性rs1625579与该疾病相关联，但其结果并不一致。这项荟萃分析的目的是评估rs1625579与精神分裂症之间的关系。数据是从电子数据库中获得的，使用RevMan 5.3软件使用具有95％置信区间（95％CI）的合并比值比（OR）来测试关联。包括十二个病例对照研究，包括11,583个病例和14315个对照。估计的lambda值为0.46，这表明最有可能建立一个显性遗传模型。在等位基因下建立了统计学上的显着关联（T vs G：OR = 1.15，95％CI = 1.10-1.21，P vs GG：OR = 1.32，95％CI = 1.13-1.54，P vs GG：OR = 1.14，95 ％CI = 0.97-1.34，P = 0.11）。这项荟萃分析表明，rs1625579 miR-137遗传变异显着增加了精神分裂症的风险。

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