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首页> 外文期刊>Genetics and Molecular Research >Differences in the number of hemocytes in the snail host Biomphalaria tenagophila, resistant and susceptible to Schistosoma mansoni infection
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Differences in the number of hemocytes in the snail host Biomphalaria tenagophila, resistant and susceptible to Schistosoma mansoni infection

机译：蜗牛宿主曼氏血吸虫的耐药性和易感性的蜗牛寄主Biomphalaria tenagophila中血细胞数量的差异

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The relationships between schistosomiasis and its intermediate host, mollusks of the genus Biomphalaria, have been a concern for decades. It is known that the vector mollusk shows different susceptibility against parasite infection, whose occurrence depends on the interaction between the forms of trematode larvae and the host defense cells. These cells are called amebocytes or hemocytes and are responsible for the recognition of foreign bodies and for phagocytosis and cytotoxic reactions. The defense cells mediate the modulation of the resistant and susceptible phenotypes of the mollusk. Two main types of hemocytes are found in the Biomphalaria hemolymph: the granulocytes and the hyalinocytes. We studied the variation in the number (kinetics) of hemocytes for 24 h after exposing the parasite to genetically selected and non-selected strains of Biomphalaria tenagophila, susceptible or not to infection by Schistosoma mansoni. The differences were analyzed referred to the variations in the number of hemocytes in mollusks susceptible or not to infection by S. mansoni. The hemolymph of the selected and non-selected snails was collected, and hemocytes were counted using a Neubauer chamber at six designated periods: 0 h (control, non-exposed individuals), 2 h, 6 h, 12 h, 18 h and, 24 h after parasite exposure. Samples of hemolymph of five selected mollusks and five non-selected mollusks were separately used at each counting time. There was a significant variation in the number of hemocytes between the strains, which indicates that defense cells have different behaviors in resistant and susceptible mollusks.
机译：数十年来，血吸虫病与其中间宿主生物淋巴菌属的软体动物之间的关系一直令人关注。已知媒介软体动物对寄生虫感染表现出不同的敏感性，其发生取决于吸虫的幼虫形式与宿主防御细胞之间的相互作用。这些细胞称为成肌细胞或血细胞，负责识别异物，吞噬作用和细胞毒性反应。防御细胞介导了软体动物抗性和易感表型的调节。在Biomphalaria血淋巴中发现了两种主要类型的血细胞：粒细胞和透明质细胞。我们研究了寄生虫暴露于遗传选择的和未选择的，对曼氏血吸虫易感或不易感染的Biomphalaria tenagophila菌株的24小时后血细胞数量（动力学）的变化。分析差异的原因是易受曼氏沙门氏菌感染的软体动物中的血细胞数量变化。收集选定和未选定的蜗牛的血淋巴，并使用Neubauer室在以下六个指定时间段对血细胞计数：0小时（对照，未暴露个体），2小时，6小时，12小时，18小时和寄生虫暴露后24小时。在每个计数时间分别使用五个选定的软体动物和五个未选定的软体动物的血淋巴样品。菌株之间的血细胞数量存在显着差异，这表明防御细胞在抗性和易感软体动物中具有不同的行为。

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