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Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity

机译：跨物种功能组分析将与DNA修复，翻译和有氧呼吸有关的蛋白质鉴定为紫外线毒性的保守调节剂

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Cellular responses to DNA damage can prevent mutations and death. In this study, we have used high throughput screens and developed a comparative genomic approach, termed Functionome mapping, to discover conserved responses to UVC-damage. Functionome mapping uses gene ontology (GO) information to link proteins with similar biological functions from different organisms, and we have used it to compare 303, 311 and 288 UVC-toxicity modulating proteins from Escherichia coli, Schizosaccharomyces pombe and Saccharomyces cerevisiae, respectively. We have demonstrated that all three organisms use DNA repair, translation and aerobic respiration associated processes to modulate the toxicity of UVC, with these last two categories highlighting the importance of ribosomal proteins and electron transport machinery. Our study has demonstrated that comparative genomic approaches can be used to identify conserved responses to damage, and suggest roles for translational machinery and components of energy metabolism in optimizing the DNA damage response.
机译：细胞对DNA损伤的反应可以防止突变和死亡。在这项研究中，我们使用了高通量筛选，并开发了一种比较基因组方法，称为功能组映射，以发现对UVC损伤的保守反应。 Functionome Mapping使用基因本体论（GO）信息来链接具有不同生物体相似生物学功能的蛋白质，并且我们已经使用它来比较了分别来自大肠杆菌，粟酒裂殖酵母和啤酒酵母的303、311和288种UVC毒性调节蛋白。我们已经证明，所有这三种生物都使用DNA修复，翻译和有氧呼吸相关的过程来调节UVC的毒性，后两类突出了核糖体蛋白和电子转运机制的重要性。我们的研究表明，可比较的基因组方法可用于鉴定保守的损伤反应，并提出转化机制和能量代谢成分在优化DNA损伤反应中的作用。

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