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Investigating the genome diversity of B. cereus and evolutionary aspects of B. anthracis emergence

机译：调查蜡状芽孢杆菌的基因组多样性和炭疽芽孢杆菌的进化方面

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Here we report the use of a multi-genome DNA microarray to investigate the genome diversity of Bacillus cereus group members and elucidate the events associated with the emergence of Bacillus anthracis the causative agent of anthrax—a lethal zoonotic disease. We initially performed directed genome sequencing of seven diverse B. cereus strains to identify novel sequences encoded in those genomes. The novel genes identified, combined with those publicly available, allowed the design of a “species” DNA microarray. Comparative genomic hybridization analyses of 41 strains indicate that substantial heterogeneity exists with respect to the genes comprising functional role categories. While the acquisition of the plasmid-encoded pathogenicity island (pXO1) and capsule genes (pXO2) represents a crucial landmark dictating the emergence of B. anthracis, the evolution of this species and its close relatives was associated with an overall shift in the fraction of genes devoted to energy metabolism, cellular processes, transport, as well as virulence.
机译：在这里，我们报告了使用多基因组DNA微阵列研究蜡状芽孢杆菌组成员的基因组多样性，并阐明了与炭疽芽孢杆菌（一种致死的人畜共患病炭疽病）的出现相关的事件。我们最初对7种不同的蜡状芽孢杆菌菌株进行了定向基因组测序，以鉴定在这些基因组中编码的新序列。鉴定出的新基因与可公开获得的基因相结合，可以设计“物种” DNA微阵列。对41个菌株进行的比较基因组杂交分析表明，就构成功能角色类别的基因而言，存在很大的异质性。尽管质粒编码的致病性岛（pXO1）和荚膜基因（pXO2）的获得是决定炭疽芽孢杆菌出现的关键标志，但该物种及其近缘种的进化与整体转化有关。致力于能量代谢，细胞过程，运输和毒力的基因。

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