Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma

Ki-Yeol Kim; Xianglan Zhang; In-Ho Cha

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Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma

机译：联合基因组表达作为口腔鳞状细胞癌的诊断因素

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Trendsingeneticsaretransforminginordertoidentifydifferentialcoexpressionsofcorrelatedgeneexpressionratherthanthesignificantindividualgene.Moreover,itisknownthatacombinedbiomarkerpatternimprovesthediscriminationofaspecificcancer.Theidentificationofthecombinedbiomarkerisalsonecessaryfortheearlydetectionofinvasiveoralsquamouscellcarcinoma(OSCC).ToidentifythecombinedbiomarkerthatcouldimprovethediscriminationofOSCC,weexploredanappropriatenumberofgenesinacombinedgenesetinordertoattainthehighestlevelofaccuracy.Afterdetectingasignificantgeneset,includingthepre-definednumberofgenes,acombinedexpressionwasidentifiedusingtheweightsofgenesinageneset.WeusedthePrincipalComponentAnalysis(PCA)fortheweightcalculation.Inthisprocess,weusedthreepublicmicroarraydatasets.Onedatasetwasusedforidentifyingthecombinedbiomarker,andtheothertwodatasetswereusedforvalidation.Thediscriminationaccuracywasmeasuredbytheout-of-bag(OOB)error.Therewasnorelationbetweenthesignificanceandthediscriminationaccuracyineachindividualgene.Theidentifiedgenesetincludedbothsignificantandinsignificantgenes.OneofthemostsignificantgenesetsintheclassificationofnormalandOSCCincludedemMMP1/em,emSOCS3/emandemACOX1/em.Furthermore,inthecaseoforaldysplasiaandOSCCdiscrimination,twocombinedbiomarkerswereidentified.Thecombinedexpressionrevealedgoodperformanceinthevalidationdatasets.Thecombinedgenomicexpressionachievedbetterperformanceinthediscriminationofdifferentconditionsthanasinglesignificantgene.Therefore,itcouldbeexpectedthataccuratediagnosisforcancercouldbepossiblewithacombinedbiomarker./p/div

机译：Trendsingeneticsaretransforminginordertoidentifydifferentialcoexpressionsofcorrelatedgeneexpressionratherthanthesignificantindividualgene.Moreover，itisknownthatacombinedbiomarkerpatternimprovesthediscriminationofaspecificcancer.Theidentificationofthecombinedbiomarkerisalsonecessaryfortheearlydetectionofinvasiveoralsquamouscellcarcinoma（鳞癌）.ToidentifythecombinedbiomarkerthatcouldimprovethediscriminationofOSCC，weexploredanappropriatenumberofgenesinacombinedgenesetinordertoattainthehighestlevelofaccuracy.Afterdetectingasignificantgeneset，includingthepre-definednumberofgenes，acombinedexpressionwasidentifiedusingtheweightsofgenesinageneset.WeusedthePrincipalComponentAnalysis（PCA）fortheweightcalculation.Inthisprocess，weusedthreepublicmicroarraydatasets.Onedatasetwasusedforidentifyingthecombinedbiomarker，andtheothertwodatasetswereusedforvalidation.Thediscriminationaccuracywasmeasuredbytheout球袋（OOB）error.Therewasnorelationbetweenthesignificanceandthediscriminationaccuracyineachindividua lgene.Theidentifiedgenesetincludedbothsignificantandinsignificantgenes.OneofthemostsignificantgenesetsintheclassificationofnormalandOSCCincluded MMP1 ， SOCS3 和 ACOX1 。再者，inthecaseoforaldysplasiaandOSCCdiscrimination，twocombinedbiomarkerswereidentified.Thecombinedexpressionrevealedgoodperformanceinthevalidationdatasets.Thecombinedgenomicexpressionachievedbetterperformanceinthediscriminationofdifferentconditionsthanasinglesignificantgene.Therefore，itcouldbeexpectedthataccuratediagnosisforcancercouldbepossiblewithacombinedbiomarker。 展开▼

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《Genomics》 |2014年第2014期|共页

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Ki-Yeol Kim; Xianglan Zhang; In-Ho Cha;
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中图分类医学遗传学;

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1. Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma [J] . KimK.-Y., ZhangX., ChaI.-H. Genomics . 2014,第5a6期

机译：联合基因组表达作为口腔鳞状细胞癌的诊断因素

2. State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma [J] . Junya Ishiwata, Atsushi Kasamatsu, Kentaro Sakuma, International journal of oncology . 2011,第1期

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3. Cytoplasmic HuR expression: Correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells [J] . ChaJ.-D., KimH.-K., ChaI.-H. Head and neck: Journal for the sciences and specialities of the head and neck . 2014,第8期

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Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma

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