H3K4me2 reliably defines transcription factor binding regions in different cells

Ying Wang; Xiaoman Li; Haiyan Hu

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H3K4me2 reliably defines transcription factor binding regions in different cells

机译：H3K4me2可靠地定义了不同细胞中的转录因子结合区

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Histonemodification(HM)patternsarewidelyappliedtoidentifytranscriptionfactorbindingregions(TFBRs).However,howfrequentlytheTFBRsoverlapwithgenomicregionsenrichedwithcertaintypesofHMsandwhichHMmarkerismoreeffectivetopinpointtheTFBRshavenotbeensystematicallyinvestigated.Toaddresstheseproblems,westudied149transcriptionfactor(TF)ChIP-seqdatasetsand33HMChIP-seqdatasetsinthreecelllines.Wefoundthatonaverageabout90%oftheTFBRsoverlapwiththeH3K4me2-enrichedregions.Moreover,theH3K4me2-enrichedregionswithstrongersignalsofH3K4me2enrichmentmorelikelyoverlapwiththeTFBRsthanthosewithweakersignals.Inaddition,weshowedthattheH3K4me2-enrichedregionstogetherwiththeH3K27ac-enrichedregionscangreatlyreducefalsepositivepredictionsoftheTFBRs.OurstudyshedslightonthecomprehensivediscoveryoftheTFBRsusingtheHeK4me-enrichedregions,especiallywhennogoodantibodytoaTFexists./p/div

机译：Histonemodification（HM）patternsarewidelyappliedtoidentifytranscriptionfactorbindingregions（TFBRs）。然而，howfrequentlytheTFBRsoverlapwithgenomicregionsenrichedwithcertaintypesofHMsandwhichHMmarkerismoreeffectivetopinpointtheTFBRshavenotbeensystematicallyinvestigated.Toaddresstheseproblems，westudied149transcriptionfactor（TF）的ChIP-seqdatasetsand33HMChIP-seqdatasetsinthreecelllines.Wefoundthatonaverageabout90％oftheTFBRsoverlapwiththeH3K4me2-enrichedregions.Moreover，theH3K4me2-enrichedregionswithstrongersignalsofH3K4me2enrichmentmorelikelyoverlapwiththeTFBRsthanthosewithweakersignals.Inaddition，weshowedthattheH3K4me2-enrichedregionstogetherwiththeH3K27ac-enrichedregionscangreatlyreducefalsepositivepredictionsoftheTFBRs.OurstudyshedslightonthecomprehensivediscoveryoftheTFBRsusingtheHeK4me-enrichedregions，especiallywhennogoodantibodytoaTFexists

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《Genomics》 |2014年第2014期|共页
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Ying Wang; Xiaoman Li; Haiyan Hu;
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1. H3K4me2 reliably defines transcription factor binding regions in different cells [J] . WangY., LiX., HuH. Genomics . 2014,第2a3期

机译：H3K4me2可靠地定义了不同细胞中的转录因子结合区
2. H3K4me2 reliably defines transcription factor binding regions in different cells [J] . WangY., LiX., HuH. Genomics . 2014,第2a3期

机译：H3K4ME2可靠地定义不同细胞中的转录因子结合区域
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7. H3K4me2 reliably defines transcription factor binding regions in different cells [O] . Wang Ying, Li Xiaoman, Hu Haiyan 2014

机译：H3K4me2可靠地定义了不同细胞中的转录因子结合区

H3K4me2 reliably defines transcription factor binding regions in different cells

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