Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss

Rajiv Madathiparambil Joseph

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Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss

机译：Neuronatin基因：印记和错误折叠：Lafora疾病，糖尿病和癌症研究可能暗示NNAT聚集体是神经元丢失的常见下游参与者

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emNeuronatin(NNAT)/emisaubiquitousandhighlyconservedmammaliangeneinvolvedinbraindevelopment.ItsmRNAisoforms,chromosomallocation,genomicDNAstructureandregulationhavebeencharacterized.Morerecentlytherehasbeenrapidprogressintheunderstandingofitsfunctioninphysiologyandhumandisease.Inparticularthereisfairlydirectevidenceimplicatingemneuronatin/eminthecausationofLaforadiseaseanddiabetes.emNeuronatin/emproteinhasastrongpredispositiontomisfoldandformcellularaggregatesthatcausecelldeathbyapoptosis.AggregationofemNeuronatin/emwithincorticalneuronsandresultingcelldeathisthehallmarkofLaforadisease,aprogressiveandfatalneurodegenerativedisease.Underhighglucoseconditionssimulatingdiabetes,emneuronatin/emproteinalsoaccumulatesanddestroyspancreaticbetacells./ppid="sp0010"Theemneuronatin/emgeneisimprintedandonlythepaternalalleleisnormallyexpressedintheadult.However,changesinDNAmethylationmaycausethematernalalleletoloseimprintingandtriggercellproliferationandmetastasis.emNeuronatin/emhasalsobeenshowntobetranslatedperipherallywithinthedendritesofneurons,afindingofrelevanceinsynapticplasticity.Thecurrentunderstandingofthefunctionofemneuronatin/emraisesthepossibilitythatthisgenemayparticipateinthecommondownstreammechanismsassociatedwithaberrantneuronalgrowthanddeath.AbetterunderstandingofthesemechanismsmayopennewtherapeutictargetstohelpmodifytheprogressionofdevastatingneurodegenerativeconditionssuchasAlzheimer'sandanteriorhorncelldisease./p/div

机译： Neuronatin（NNAT） isaubiquitousandhighlyconservedmammaliangeneinvolvedinbraindevelopment.ItsmRNAisoforms，染色体分配，genomicDNAstructureandregulationhavebeencharacterized.Morerecentlytherehasbeenrapidprogressintheunderstandingofitsfunctioninphysiologyandhumandisease.Inparticularthereisfairlydirectevidenceimplicating neuronatin inthecausationofLaforadiseaseanddiabetes。 Neuronatin proteinhasastrongpredispositiontomisfoldandformcellularaggregatesthatcausecelldeathbyapoptosis.Aggregationof Neuronatin withincorticalneuronsandresultingcelldeathisthehallmarkofLaforadisease，aprogressiveandfatalneurodegenerativedisease.Underhighglucoseconditionssimulatingdiabetes， neuronatin proteinalsoaccumulatesanddestroyspancreaticbetacells。的 neuronatin geneisimprintedandonlythepaternalalleleisnormallyexpressedintheadult.However，changesinDNAmethylationmaycausethematernalalleletoloseimprintingandtriggercellproliferationandmetastasis。新ronatin hasalsobeenshowntobetranslatedperipherallywithinthedendritesofneurons，afindingofrelevanceinsynapticplasticity.Thecurrentunderstandingofthefunctionof neuronatin raisesthepossibilitythatthisgenemayparticipateinthecommondownstreammechanismsassociatedwithaberrantneuronalgrowthanddeath.AbetterunderstandingofthesemechanismsmayopennewtherapeutictargetstohelpmodifytheprogressionofdevastatingneurodegenerativeconditionssuchasAlzheimer'sandanteriorhorncelldisease。 展开▼

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《Genomics》 |2014年第2014期|共页

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Rajiv Madathiparambil Joseph;
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中图分类医学遗传学;

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1. Neuronatin gene: Imprinted and misfolded. Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss [J] . JosephR.M. Genomics . 2014,第2a3期

机译：Neuronatin基因：印记和错误折叠。对Lafora疾病，糖尿病和癌症的研究可能暗示NNAT聚集体是神经元丢失的常见下游参与者

2. Neuronatin gene: Imprinted and misfolded. Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss [J] . JosephR.M. Genomics . 2014,第2a3期

机译：神经阴性基因：印迹和错误折叠。 Lafora病，糖尿病和癌症的研究可能将NNAT-作为神经元损失的常见下游参与者致癌

3. PROX1 gene CC genotype as a major determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation study [J] . Hamet Pavel, Haloui Mounsif, Harvey Francois, Journal of hypertension . 2017,第Suppla1期

机译：Prox1基因CC基因型作为糖尿病和血管疾病作用中的斯拉夫研究参与者在斯拉夫研究参与者中早期发作的主要决定因素：Preterax和Diamicrol MR控制评估研究

4. Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies [C] . Erdahl T Teber, Jason Y Liu, Sara Ballouz, The 7th Asia-Pacific Bioinformatics Conference（第七届亚太生物信息学大会） . 2009

机译：通过全基因组关联研究比较使用涉及2型糖尿病的基因的自动候选基因预测系统

5. Novel regulation of neuronal genes implicated in Alzheimer disease by microRNA [D] . Long, Justin M. 2013

机译：microRNA对涉及阿尔茨海默病的神经元基因的新调控

6. Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases [O] . Kwang Hun Lim 2019

机译：多种错误折叠的构象菌株和涉及神经退行性疾病的错误折叠的蛋白质的交叉播种。

7. Neuronatin gene: Imprinted and misfolded Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss [O] . Joseph Rajiv Madathiparambil 2014

机译：Neuronatin基因：印迹和折叠错误在Lafora疾病，糖尿病和癌症中的研究可能暗示NNAT聚集体是神经元丢失的常见下游参与者

1. 糖尿病研究有可能为自体免疫疾病的基因治疗提供新的可能性 [J] . 王颖 . 生物技术通报 . 1996,第002期

1. neuroregeneration induction method, neuron protection method against neuronal loss or damage, neurodegenerative disease prevention or treatment method due to neuronal loss or damage, and drug candidate screening method for the treatment of neurodegenerative disease [P] . 外国专利： BR112019009711A2 . 2019-08-13

机译：神经再生诱导方法，针对神经元丢失或损害的神经元保护方法，由于神经元丢失或损害引起的神经退行性疾病预防或治疗方法以及用于治疗神经退行性疾病的候选药物筛选方法

2. A compound, pharmaceutical composition, processes for treating or preventing cancer, a disease in which angiogenesis is implicated, retinal vascularization, diabetic retinopathy, age-related macular degeneration, inflammatory diseases, tyrosine-dependent disease or conditions. kinase, bone-associated pathologies, and processes for producing a pharmaceutical composition, and for reducing or preventing tissue damage following a cerebral ischemic event [P] . 外国专利： BR0013899A . 2003-07-08

机译：一种化合物，药物组合物，用于治疗或预防癌症，涉及血管生成的疾病，视网膜血管形成，糖尿病性视网膜病，年龄相关性黄斑变性，炎性疾病，酪氨酸依赖性疾病或病症的方法。激酶，骨相关病理学和药物组合物的生产方法，以及减少或预防脑缺血事件后组织损伤的方法

3. Phenyl or phenyl-goblin 3,2-b pyridine compounds, thyroid hormone 500 inhibitors; pharmacological synthesis; used in the treatment of colon cancer, lung cancer, hematopoietic disease, liver cancer, breast cancer, diabetic retinopathy, degenerative diseases, glaucoma, abscess, diabetes, patients Neurological degeneration, etc. [P] . 外国专利： CL2012000592A1 . 2012-08-03

机译：苯基或地精[3,2-b]吡啶化合物，甲状腺激素500抑制剂;药理合成用于治疗结肠癌，肺癌，造血系统疾病，肝癌，乳腺癌，糖尿病性视网膜病变，退行性疾病，青光眼，脓肿，糖尿病，患者神经系统变性等。

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Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss

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