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首页> 外文期刊>Genomics Insights >Molecular Cloning of a Novel Bradykinin-Related Peptide from the Skin of Indian Bronzed Frog Hylarana Temporalis:
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Molecular Cloning of a Novel Bradykinin-Related Peptide from the Skin of Indian Bronzed Frog Hylarana Temporalis:

机译：从印度古铜色的青蛙Hylarana Temporalis皮肤的新型缓激肽相关肽的分子克隆：

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摘要

Bradykinin-related peptides (BRPs) constitute one of the most studied groups of bioactive peptides in amphibian skin secretions. The present study describes the successful isolation of a novel BRP (hylaranakinin TE) from the skin secretion of the Indian bronzed frog Hylarana temporalis. The deduced open reading frame consisted of 115 amino acid residues with a putative signal peptide of 22 amino acid residues, followed by a spacer region and mature peptide regions that encode for two BRPs: a canonical bradykinin R-9-R with a C-terminal extension of FVPASSL and Thr6-BK. The Thr6-BK reported in the present study had an unusual FP-insertion in the N-terminal part and ended in FAPEII, which is very different from the IAPAIV sequence reported in other ranid frogs. Unlike the mammalian bradykinin and its precursor, amphibian BRPs and their precursors are extremely variable, as evident from the present study. This forms the first report of BRPs from Hylarana temporalis, endemic to India and Sri Lanka.
机译：缓激肽相关肽（BRP）构成两栖动物皮肤分泌物中研究最多的生物活性肽之一。本研究描述了从印度古铜色青蛙Hylaranatempalis皮肤分泌物中成功分离出一种新型BRP（透明质酸TE）的方法。推导的开放阅读框由115个氨基酸残基和22个氨基酸残基的假定信号肽组成，其后是间隔区和编码两个BRP的成熟肽区：典型的缓激肽R-9-R，具有C端FVPASSL和Thr6-BK的扩展。在本研究中报道的Thr6-BK在N末端部分有异常的FP插入，并以FAPEII结尾，这与其他蛙类蛙中报道的IAPAIV序列非常不同。与哺乳动物缓激肽及其前体不同，两栖动物BRP及其前体变化极大，从本研究中可以明显看出。这是印度和斯里兰卡特有的Hylaranatempalis的BRP的首次报告。

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