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首页> 外文期刊>Genomics >Towards diversity in genomics: The emergence of neurogenomics in Africa?
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Towards diversity in genomics: The emergence of neurogenomics in Africa?

机译：走向基因组学的多样性：非洲神经基因组学的出现？

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There is a high burden of mental and neurological disorders in Africa. Nevertheless, there appears to be an under-representation of African ancestry populations in large-scale genomic studies. Here, we evaluated the extent of under-representation of Africans in neurogenomic studies in the GWAS Catalog. We found 569 neurogenomic studies, of which 88.9% were exclusively focused on people with European ancestry and the remaining 11.1% having African ancestry cases included. In terms of population, only 1.2% of the total populations involved in these 569 GWAS studies were of African descent. Further, most of the individuals in the African ancestry category were identified to be African-Americans/Afro-Caribbeans, highlighting the huge under-representation of homogenous African populations in large-scale neurogenomic studies. Efforts geared at establishing strong collaborative ties with European/American researchers, maintaining freely accessible biobanks and establishing comprehensive African genome data repositories to track African genome variations are critical for propelling neurogenomics/precision medicine in Africa.
机译：在非洲，精神和神经系统疾病负担沉重。然而，在大规模基因组研究中，非洲血统的人口似乎不足。在这里，我们评估了GWAS目录中神经基因组研究中非洲人代表性不足的程度。我们发现569项神经基因组研究，其中88.9％专门针对欧洲血统的人群，其余11.1％包括非洲血统的人群。就人口而言，这569个GWAS研究涉及的总人口中只有1.2％是非洲人后裔。此外，非洲血统类别中的大多数个人被确定为非裔美国人/非洲加勒比海地区，这突显了大规模神经基因组研究中同质非洲人口的巨大不足。致力于与欧美研究人员建立牢固的合作关系，维护可自由访问的生物库以及建立全面的非洲基因组数据库以追踪非洲基因组变异的努力对于推动非洲神经基因组学/精密医学至关重要。

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