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Whole genome DNA methylation profiling of oral cancer in ethnic population of Meghalaya, North East India reveals novel genes

机译：印度东北部梅加拉亚邦人群口腔癌的全基因组DNA甲基化分析揭示了新基因

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Oral Squamous Cell Carcinoma (OSCC) is a serious and one of the most common and highly aggressive malignancies. Epigenetic factors such as DNA methylation have been known to be implicated in a number of cancer etiologies. The main objective of this study was to investigate physiognomies of Promoter DNA methylation patterns associated with oral cancer epigenome with special reference to the ethnic population of Meghalaya, North East India. The present study identifies 27,205 CpG sites and 3811 regions that are differentially methylated in oral cancer when compared to matched normal. 45 genes were found to be differentially methylated within the promoter region, of which 38 were hypermethylated and 7 hypomethylated. 14 of the hypermethylated genes were found to be similar to that of the TCGA-HNSCC study some of which are TSGs and few novel genes which may serve as candidate methylation biomarkers for OSCC in this poorly characterized ethnic group.
机译：口腔鳞状细胞癌（OSCC）是一种严重的恶性肿瘤，是最常见和高度侵袭性的恶性肿瘤之一。已知表观遗传因素（例如DNA甲基化）与许多癌症病因有关。这项研究的主要目的是研究与口腔癌表观基因组相关的启动子DNA甲基化模式的生理学，特别是针对印度东北部梅加拉亚邦的族群。本研究确定了与匹配的正常人相比在口腔癌中甲基化差异的27,205个CpG位点和3811个区域。发现45个基因在启动子区域内差异甲基化，其中38个是超甲基化的，而7个是低甲基化的。发现14个高甲基化基因与TCGA-HNSCC研究的相似，其中一些是TSG，而很少有新基因可以作为该特征较弱的种族中OSCC的候选甲基化生物标记。

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