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首页> 外文期刊>Genomics >Gastrocnemius transcriptome analysis reveals domestication induced gene expression changes between wild and domestic chickens
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Gastrocnemius transcriptome analysis reveals domestication induced gene expression changes between wild and domestic chickens

机译：腓肠肌转录组分析显示驯化诱导的野生和家养鸡之间的基因表达变化

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Artificial selection of chicken for human-preferred traits has manifested great phenotypic differences between wild and domestic chickens. Study on the formation of these phenotypic variations will contribute to comprehensive understanding of the molecular mechanism of animal domestication. We used three kinds of chicken breeds for transcriptome analysis, including the red jungle fowl which was the wild ancestor of chickens, and two other domestic breeds, the chahua chicken and the avian broiler. More than 12,000 genes' expression levels were compared between different chicken breeds, and hundreds of genes displayed differential expression levels compared with wild chicken. Gene ontology analysis showed that differentially expressed genes in domestic chickens tended to be enriched in extracellular matrix, DNA binding and immune system development, etc. Some genes with important biological functions were differentially expressed in the domestic chickens, including titin, myostatin ubiquitin related genes, and transforming growth factor-beta receptor III, indicating possible selection pressures on these genes.
机译：人工选择具有人类偏爱性状的鸡表现出野生和家养鸡之间存在很大的表型差异。这些表型变异的形成的研究将有助于全面了解动物驯化的分子机制。我们使用了三种鸡种进行转录组分析，包括作为鸡的原始祖先的红色丛林禽，以及另外两种国产种，即茶花鸡和禽肉鸡。在不同鸡种之间比较了超过12,000个基因的表达水平，与野生鸡相比，数百个基因显示出不同的表达水平。基因本体分析表明，家鸡体内差异表达的基因倾向于富含细胞外基质，DNA结合和免疫系统发育等。家鸡体内一些具有重要生物学功能的基因差异表达，其中包括titin，myostatin ubiquitin相关基因，以及转化生长因子-β受体III，表明这些基因可能面临选择压力。

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