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首页> 外文期刊>Genomics >Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development
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Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development

机译：小鼠胚胎和胎盘发育过程中IG-DMR和Gtl2-DMR的甲基化动力学

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The Dlk1-Dio3 imprinted domain on mouse chromosome 12 contains IG-DMR and Gtl2-DMR, whose methylation patterns are established in the germline and after fertilization, respectively. In this study, we determine that acquisition of DNA methylation at the paternal allele of the Gtl2-DMR is initiated after the blastocyst stage and completed by embryonic day 6.5, and that Gtl2 (approved symbol: Meg3) is monoallelically expressed from the maternal allele as early as the blastocyst. Therefore, DNA methylation at the Gtl2-DMR is not a prerequisite for the imprinted expression of Gtl2, which may be involved in the control of proliferation and differentiation of cells during early gestation. We also reveal that a subregion of the IG-DMR exhibits tissue-specific differences in allelic methylation patterns. These results add to the growing body of knowledge elucidating the mechanism whereby parent-of-origin-dependent DNA methylation at the IG-DMR leads to the imprinted expression of the Dlk1-Dio3 cluster.
机译：小鼠12号染色体上的Dlk1-Dio3印迹域包含IG-DMR和Gtl2-DMR，它们的甲基化模式分别在种系中和受精后建立。在这项研究中，我们确定在胚泡期后开始在Gtl2-DMR的父本等位基因中获取DNA甲基化，并在胚胎第6.5天完成，并且Gtl2（批准的符号：Meg3）从母本等位基因中单等位表达为早为胚泡。因此，在Gtl2-DMR处的DNA甲基化不是Gtl2的印迹表达的先决条件，Gtl2的印迹表达可能参与早期妊娠期间细胞的增殖和分化的控制。我们还揭示了IG-DMR的一个子区域在等位基因甲基化模式中表现出组织特异性差异。这些结果增加了不断发展的知识，阐明了IG-DMR上依赖于母本的DNA甲基化导致Dlk1-Dio3簇印记表达的机理。

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