Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways

Fransiskus X. Ivan; K.S. Tan; M.C. Phoon; Bevin P. Engelward; Roy E. Welsch; Jagath C. Rajapakse; Vincent T. Chow

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Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways

机译：感染高毒力H3N2流感病毒的中性粒细胞显示出早期细胞死亡增加和I型干扰素信号传导途径的快速诱导

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WedevelopedamodelofinfluenzavirusinfectionofneutrophilsbyinducingdifferentiationoftheMPROpromyelocyticcellline.After5#xA0;daysofdifferentiation,about20ndash;30%ofmatureneutrophilscouldbedetected.Onlyafractionofneutrophilswereinfectedbyhighlyvirulentinfluenza(HVI)virus,butwereunabletosupportactiveviralreplicationcomparedwithMDCKcells.HVIinfectionofneutrophilsaugmentedearlyandlateapoptosisasindicatedbyannexinVandTUNELassays.ComparisonbetweentheglobaltranscriptomicresponsesofneutrophilstoHVIandlowvirulentinfluenza(LVI)revealedthattheIFNregulatoryfactorandIFNsignalingpathwayswerethemostsignificantlyoverrepresentedpathways,withactivationofrelatedgenesinHVIasearlyas3#xA0;h.Relativelyconsistentresultswereobtainedbyreal-timeRT-PCRofselectedgenesassociatedwiththetypeIIFNpathway.EarlyafterHVIinfection,comparativelyenhancedexpressionofapoptosis-relatedgeneswasalsoelicited./p/div

机译：WedevelopedamodelofinfluenzavirusinfectionofneutrophilsbyinducingdifferentiationoftheMPROpromyelocyticcellline.After5＃XA0; daysofdifferentiation，about20ndash; 30％ofmatureneutrophilscouldbedetected.Onlyafractionofneutrophilswereinfectedbyhighlyvirulentinfluenza（HVI）病毒，butwereunabletosupportactiveviralreplicationcomparedwithMDCKcells.HVIinfectionofneutrophilsaugmentedearlyandlateapoptosisasindicatedbyannexinVandTUNELassays.ComparisonbetweentheglobaltranscriptomicresponsesofneutrophilstoHVIandlowvirulentinfluenza（LVI）revealedthattheIFNregulatoryfactorandIFNsignalingpathwayswerethemostsignificantlyoverrepresentedpathways，withactivationofrelatedgenesinHVIasearlyas3＃XA0; h.Relativelyconsistentresultswereobtainedbyreal-timeRT-PCRofselectedgenesassociatedwiththetypeIIFNpathway.EarlyafterHVIinfection，comparativelyenhancedexpressionofapoptosis-relatedgeneswasalsoelicited

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《Genomics》 |2013年第2期|共页
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Fransiskus X. Ivan; K.S. Tan; M.C. Phoon; Bevin P. Engelward; Roy E. Welsch; Jagath C. Rajapakse; Vincent T. Chow;
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中图分类医学遗传学;
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1. Neutrophils Infected with highly virulent Influenza H3N2 virus exhibit augmented early cell death and rapid Induction of type I interferoe signaling pathways [J] . Fransiskus X. Ivan, K.S. Tan, M.C. Phoon, Genomics . 2013,第2期

机译：感染高毒力H3N2流感病毒的中性粒细胞显示出增加的早期细胞死亡和I型干扰素信号传导途径的快速诱导
2. Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines [J] . Ivan F.X., Rajapakse J.C., Welsch R.E., Functional & integrative genomics . 2012,第1期

机译：在感染了低毒和高毒力H3N2流感病毒的鼠肺中，不同的肺转录组谱显示出TREM1信号传导，细胞因子和趋化因子的调节异常
3. Induction of inflammatory cytokines and toll-like receptors in human normal respiratory epithelial cells infected with seasonal H1N1, 2009 pandemic H1N1, seasonal H3N2, and highly pathogenic H5N1 influenza virus. [J] . Song BM, Kang YM, Kim HS, Viral immunology . 2011,第3期

机译：在感染了季节性H1N1、2009大流行H1N1，季节性H3N2和高致病性H5N1流感病毒的人类正常呼吸道上皮细胞中诱导炎性细胞因子和toll样受体。
4. The Signal Pathways Of Immune Inflammation Mediated By The Tlr3/Nf-Kappab And Activator Protein-1 In Cells Infected With Influenza A Virus Antagonized By Baicalin [C] . Chunjing Zhang, Haitao Yu International Conference on Smart Materials and Nanotechnology in Engineering . 2012

机译：在感染甲虫拮抗的细胞中介导的TLR3 / NF-κB和活化剂蛋白-1介导的免疫炎症的信号途径
5. Type 2 Bovine Viral Diarrhea Virus Npro Suppresses Type I Inteferon Pathway Signaling in Bovine Cells and Augments Bovine Respiratory Syncytal Virus Replication [D] . Alkheraif, Abdulrahman Abdulaziz A. 2018

机译：2型牛病毒性腹泻病毒Npro抑制牛细胞和增强物中的I型干扰素途径信号转导牛呼吸道合胞病毒复制
6. Activation of Type I and III Interferon Signalling Pathways Occurs in Lung Epithelial Cells Infected with Low Pathogenic Avian Influenza Viruses [O] . Richard Sutejo, Dawn S. Yeo, Myint Zu Myaing, 2009

机译：低病原性禽流感病毒感染的肺上皮细胞中发生I型和III型干扰素信号通路的激活
7. Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways [O] . Ivan Fransiskus X., Tan K.S., Phoon M.C., 2013

机译：感染高毒力H3N2流感病毒的中性粒细胞显示出早期细胞死亡增加和I型干扰素信号传导途径的快速诱导

Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways

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