5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels

Rachelle E. Irwin; Avinash Thakur; Karla M. O Neill; Colum P. Walsh

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5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels

机译：5-羟甲基化标记一类受基因内甲基胞嘧啶水平调节的神经元基因

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Werecentlyidentifiedaclassofneuronalgeneinheritinghighlevelsofintragenicmethylationfromthemotherandmaintainingthisthroughlaterdevelopment.Weshowherethatthesegenesareimplicatedinbasicneuronalfunctionssuchaspost-synapticsignalling,ratherthanneuronaldevelopmentandinherithighlevelsof5mC,butnot5hmC,fromthemother.5mCisdistributedacrossthegenebodyandappearstofacilitatetranscription,astranscriptionisreducedinDNAmethyltransferaseI(emDnmt1/em)knockoutembryonicstemcellsaswellasinfibroblaststreatedwithamethyltransferaseinhibitor.Howeverinadultbrain,transcriptionismorecloselyassociatedwithagainin5hmC,whichoccurswithoutameasurablelossof5mC.Thesefindingsaddtogrowingevidencethattheremaybearolefor5mCinpromotingtranscriptionaswellasitsclassicalroleingenesilencing./p/div

机译：Werecentlyidentifiedaclassofneuronalgeneinheritinghighlevelsofintragenicmethylationfromthemotherandmaintainingthisthroughlaterdevelopment.Weshowherethatthesegenesareimplicatedinbasicneuronalfunctionssuchaspost-synapticsignalling，ratherthanneuronaldevelopmentandinherithighlevelsof5mC，butnot5hmC，fromthemother.5mCisdistributedacrossthegenebodyandappearstofacilitatetranscription，astranscriptionisreducedinDNAmethyltransferaseI（ DNMT1 ）knockoutembryonicstemcellsaswellasinfibroblaststreatedwithamethyltransferaseinhibitor.Howeverinadultbrain，transcriptionismorecloselyassociatedwithagainin5hmC，whichoccurswithoutameasurablelossof5mC.Thesefindingsaddtogrowingevidencethattheremaybearolefor5mCinpromotingtranscriptionaswellasitsclassicalroleingenesilencing。 展开▼

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《Genomics》 |2014年第5期|共页

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Rachelle E. Irwin; Avinash Thakur; Karla M. O Neill; Colum P. Walsh;
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中图分类医学遗传学;

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1. 5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels [J] . Irwin Rachelle E., Thakur Avinash, ONeill Karla M., Genomics . 2014,第5期

机译：5-羟甲基化标记一类受基因内甲基胞嘧啶水平调节的神经元基因

2. Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm [J] . Jolanta Guz, Daniel Gackowski, Marek Foksinski, Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2014,第3期

机译：人白细胞和精子之间表观遗传标记5-甲基胞嘧啶，5-羟甲基胞嘧啶和5-羟甲基尿嘧啶的绝对水平的比较

3. Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm [J] . Jolanta Guz, Daniel Gackowski, Marek Foksinski, Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2014,第3期

机译：人白细胞和精子之间表观遗传标记5-甲基胞嘧啶，5-羟甲基胞嘧啶和5-羟甲基尿嘧啶的绝对水平的比较

4. The Duplication and Intragenic Domain Expansion of Human C2H2 Zinc Finger Genes Are Associated with Transposable Elements and Relevant to the Expression-based Clustering [C] . Wensheng Zhang, Andrea Edwards, Prescott Deininger, International Conference on Bioinformatics and Computational Biology . 2015

机译：人C2H2锌指基因的重复和腺体结构域膨胀与转换元件相关并与基于表达的聚类相关联

5. Interactions Between the Axon Tip and Its Environment in Regulating Neuronal Survial and Axon Regeneration: Roles of the CSPG Receptor, PTPσ, and Delayed Axolemmal Resealing [D] . Rodemer, William C. 2019

机译：轴突尖端与周围环境之间的相互作用，调节神经元存活和轴突再生：CSPG受体，PTPσ和延迟的轴突重新密封的作用。

6. Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival [O] . Yan-Wei Tan, Tina Hoffmann, Hilmar Bading 2012

机译：野生型CREB的水平升高会上调几种活性调节的死亡抑制剂（AID）基因并促进神经元存活

7. 5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels [O] . Irwin Rachelle E., Thakur Avinash, O Neill Karla M., 2014

机译：5-羟甲基化标记一类受基因内甲基胞嘧啶水平调节的神经元基因

1. 5-氮-2'-脱氧胞嘧啶对U266细胞系P16基因去甲基化作用研究 [J] . 付海英 ,沈建箴 ,叶宝国 . 白血病·淋巴瘤 . 2007,第002期

2. 基于DNA甲基化/羟甲基化水平中药调控冠心病血瘀证相关基因分子生物学研究进展 [J] . 张书萌 ,陈伶利 ,张湘卓 . 中国中医药信息杂志 . 2020,第011期

3. 老年心肌梗死患者外周血全基因组DNA甲基化和羟甲基化水平与冠状动脉粥样硬化程度的关系 [J] . 胡春晓 ,蒋丹 ,吴世勇 . 上海交通大学学报（医学版） . 2018,第007期

4. MECP2基因甲基化和羟甲基化水平的性别差异研究 [J] . 刘亚卉 ,郑煜芳 ,刘星 . 中国循证儿科杂志 . 2016,第002期

5. 液相色谱-串联质谱法同时测定生物组织全基因组DNA甲基化和羟甲基化水平 [J] . 木晓丽 ,张洁 ,彭思远 . 色谱 . 2014,第007期

6. 小鼠早期胚胎发育过程中5-羟甲基胞嘧啶与DNA主动去甲基化关系的研究 [C] . 李子义 . 第七次全国动物生物技术学术研讨会暨新疆畜牧科学院第六次学术年会 . 2013

7. 5-羟甲基化胞嘧啶全基因组测定在胃癌的探索 [A] . 李嘉鑫 . 2020

1. 一种区分DNA中5-甲基化胞嘧啶和5-羟甲基化胞嘧啶的方法 [P] . 中国专利： CN110527708A . 2019-12-03

2. DNA5-甲基胞嘧啶与5-羟甲基胞嘧啶基因图谱测序方法 [P] . 中国专利： CN105648537B . 2018.06.29

3. METHOD FOR REGULATING DIFFERENTIATION OF STEM CELLS THROUGH EPIGENETIC MODIFICATION OF INTRAGENIC CPG ISLANDS [P] . 外国专利： WO2017078216A1 . 2017-05-11

机译：通过内源性CPG岛的表观遗传修饰来调节干细胞分化的方法

4. Composition for regulating dopamine or norepinephrine levels in neuronal synapses [P] . 外国专利： EP0005058B1 . 1984-10-17

机译：用于调节神经元突触中多巴胺或去甲肾上腺素水平的组合物

5. COMPOSITION FOR REGULATING DOPAMINE OR NOREPINEPHRINE LEVELS IN NEURONAL SYNAPSES [P] . 外国专利： DE2967257D1 . 1984-11-22

机译：调节神经突触中多巴胺或去甲肾上腺素水平的组合物

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5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels

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