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首页> 外文期刊>Genomics >A computational index derived from whole-genome copy number analysis is a novel tool for prognosis in early stage lung squamous cell carcinoma
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A computational index derived from whole-genome copy number analysis is a novel tool for prognosis in early stage lung squamous cell carcinoma

机译：从全基因组拷贝数分析得出的计算指标是早期肺癌鳞状细胞癌预后的新工具

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Squamous cell carcinoma of the lung is remarkable for the extent to which the same chromosomal abnormalities are detected in individual tumours. We have used next generation sequencing at low coverage to produce high resolution copy number karyograms of a series of 89 non-small cell lung tumours specifically of the squamous cell subtype. Because this methodology is able to create karyograms from formalin-fixed paraffin-embedded material, we were able to use archival stored samples for which survival data were available and correlate frequently occurring copy number changes with disease outcome. No single region of genomic change showed significant correlation with survival. However, adopting a whole-genome approach, we devised an algorithm that relates to total genomic damage, specifically the relative ratios of copy number states across the genome. This algorithm generated a novel index, which is an independent prognostic indicator in early stage squamous cell carcinoma of the lung.
机译：肺鳞状细胞癌在个体肿瘤中检测到相同染色体异常的程度非常显着。我们已经使用了低覆盖率的下一代测序技术，以产生一系列89种非小细胞肺癌特别是鳞状细胞亚型的高分辨率拷贝数核图。因为这种方法能够从福尔马林固定石蜡包埋的材料创建核电图，所以我们能够使用保存了生存数据的档案存储样本，并将经常发生的拷贝数变化与疾病结果相关联。没有基因组变化的单个区域显示与生存显着相关。但是，采用全基因组方法，我们设计了一种与总基因组损伤有关的算法，特别是整个基因组中拷贝数状态的相对比率。该算法产生了一个新的指标，它是早期肺鳞状细胞癌的独立预后指标。

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