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首页> 外文期刊>IUCrJ >Formation of a highly dense tetra-rhenium cluster in a protein crystal and its implications in medical imaging
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Formation of a highly dense tetra-rhenium cluster in a protein crystal and its implications in medical imaging

机译：蛋白晶体中高密度四-簇的形成及其在医学成像中的意义

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The fact that a protein crystal can serve as a chemical reaction vessel is intrinsically fascinating. That it can produce an electron-dense tetranuclear rhenium cluster compound from a rhenium tri­carbonyl tri­bromo starting compound adds to the fascination. Such a cluster has been synthesized previously in vitro, where it formed under basic conditions. Therefore, its synthesis in a protein crystal grown at pH 4.5 is even more unexpected. The X-ray crystal structures presented here are for the protein hen egg-white lysozyme incubated with a rhenium tri­carbonyl tri­bromo compound for periods of one and two years. These reveal a completed, very well resolved, tetra-rhenium cluster after two years and an intermediate state, where the carbonyl ligands to the rhenium cluster are not yet clearly resolved, after one year. A dense tetranuclear rhenium cluster, and its technetium form, offer enhanced contrast in medical imaging. Stimulated by these crystallography results, the unusual formation of such a species directly in an in vivo situation has been considered. It offers a new option for medical imaging compounds, particularly when considering the application of the pre-formed tetranuclear cluster, suggesting that it may be suitable for medical diagnosis because of its stability, preference of formation and biological compatibility.
机译：蛋白质晶体可以用作化学反应容器的事实本质上令人着迷。可以从三羰基三溴化starting起始化合物生产电子致密的四核rh簇化合物，这令人着迷。这种簇先前已在体外合成，并在碱性条件下形成。因此，其在pH 4.5下生长的蛋白质晶体中的合成甚至是出乎意料的。这里介绍的X射线晶体结构是针对蛋清溶菌酶和三羰基三溴化rh化合物孵育一年和两年的蛋白质。这些结果表明，两年后，一个完整的，非常好分辨的四-簇和一个中间状态，一年后，intermediate簇的羰基配体尚未被清楚地分辨出来。密集的四核rh簇及其and形式在医学成像中提供了增强的对比度。通过这些晶体学结果的刺激，已经考虑了直接在体内情况下这种物质的异常形成。它为医学成像化合物提供了新的选择，特别是考虑到预先形成的四核簇的应用时，这表明它具有稳定性，形成偏好和生物相容性，可能适合医学诊断。

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