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首页> 外文期刊>Genetics research international >CRISPR/Cas9 System: A Bacterial Tailor for Genomic Engineering
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CRISPR/Cas9 System: A Bacterial Tailor for Genomic Engineering

机译：CRISPR / Cas9系统：基因工程的细菌裁缝

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摘要

Microbes use diverse defence strategies that allow them to withstand exposure to a variety of genome invaders such as bacteriophages and plasmids. One such defence strategy is the use of RNA guided endonuclease called CRISPR-associated (Cas) 9 protein. The Cas9 protein, derived from type II CRISPR/Cas system, has been adapted as a versatile tool for genome targeting and engineering due to its simplicity and high efficiency over the earlier tools such as ZFNs and TALENs. With recent advancements, CRISPR/Cas9 technology has emerged as a revolutionary tool for modulating the genome in living cells and inspires innovative translational applications in different fields. In this paper we review the developments and its potential uses in the CRISPR/Cas9 technology as well as recent advancements in genome engineering using CRISPR/Cas9.
机译：微生物使用多种防御策略，使它们能够承受各种基因组入侵者（如噬菌体和质粒）的暴露。一种这样的防御策略是使用称为CRISPR相关（Cas）9蛋白的RNA指导的核酸内切酶。源自II型CRISPR / Cas系统的Cas9蛋白由于其相对于ZFN和TALENs等早期工具的简单性和高效性，已被改造为用于基因组靶向和工程化的多功能工具。随着最新的发展，CRISPR / Cas9技术已经成为调节活细胞中基因组的革命性工具，并激发了不同领域的创新翻译应用。在本文中，我们回顾了CRISPR / Cas9技术的发展及其潜在用途，以及使用CRISPR / Cas9进行基因组工程的最新进展。

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