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首页> 外文期刊>Genetics research international >Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications
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Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications

机译：非编码RNA在肺癌生物学中的机制作用及其临床意义

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Lung cancer biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify oncogenes and tumor suppressors diagnostic and therapeutic targets. Another important layer of cancer biology has emerged in the form of noncoding RNAs (ncRNAs), which are major regulators of key cellular processes such as proliferation, RNA splicing, gene regulation, and apoptosis. In the past decade, microRNAs (miRNAs) have moved to the forefront of ncRNA cancer research, while the role of long noncoding RNAs (lncRNAs) is emerging. Here we review the mechanisms by which miRNAs and lncRNAs are deregulated in lung cancer, the technologies that can be applied to detect such alterations, and the clinical potential of these RNA species. An improved comprehension of lung cancer biology will come through the understanding of the interplay between deregulation of non-coding RNAs, the protein-coding genes they regulate, and how these interactions influence cellular networks and signalling pathways.
机译：肺癌生物学传统上一直专注于蛋白质编码基因的基因组和表观基因组失调，以鉴定癌基因和肿瘤抑制物的诊断和治疗靶标。癌症生物学的另一个重要方面已经以非编码RNA（ncRNA）的形式出现，它们是关键细胞过程（例如增殖，RNA剪接，基因调控和细胞凋亡）的主要调节剂。在过去的十年中，microRNA（miRNA）已移至ncRNA癌症研究的最前沿，而长非编码RNA（lncRNA）的作用正在兴起。在这里，我们回顾了肺癌中miRNA和lncRNA失控的机制，可用于检测此类改变的技术以及这些RNA种类的临床潜力。通过了解非编码RNA的解除调控，它们调控的蛋白质编码基因之间的相互作用，以及这些相互作用如何影响细胞网络和信号通路，肺癌生物学的理解将得到改善。

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