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首页> 外文期刊>Genetics research international >The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss: A Review
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The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss: A Review

机译：前庭神经鞘瘤的分子生物学及其与听力损失的关系：综述。

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摘要

Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.
机译：听力下降是前庭神经鞘瘤（VS）患者最常见的症状。过去，由肿瘤块及其生长引起的压缩机制被认为是与VS相关的听力损失的最可能原因。有趣的是，新证据提出了分子机制来解释这种听力损失。提出的分子机制包括TP73的甲基化，细胞周期蛋白D1的负表达，B7-H1的表达，血小板衍生的生长因子A的表达增加，PEX5L，RAD54B和PSMAL的过表达以及CEA的过表达。前庭神经鞘瘤的发展涉及许多分子机制。我们回顾了其中一些机制，特别强调与前庭神经鞘瘤相关的听力损失。

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