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首页> 外文期刊>Global Veterinaria >Sedative and Hematobiochemical Effects of Midazolam and Midazolam-Ketamine Combination in Baladi Goats
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Sedative and Hematobiochemical Effects of Midazolam and Midazolam-Ketamine Combination in Baladi Goats

机译：巴拉迪山羊咪达唑仑和咪达唑仑-氯胺酮组合的镇静和血液生化作用

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The concept of administering sedatives either alone or before general anaesthetic agents is wellaccepted in veterinary practice. The aim of the present study is to investigate the clinicophysiological effectsof different doses of midazolam and its suitability as a preanaesthetic to ketamine in goats. Three goats receivedone of the following treatments, with one week interval; midazolam 0.6 mg/kg body weight, 1.2 mg/kg and0.6 mg/kg followed by another dose of 0.3 mg/kg ten minutes later and finally combination of midazolam(0.6 mg/kg) and ketamine (4 mg/kg). Onset and duration of sedation and recumbancy, degree of sedation as wellas clinical parameters were recorded. Blood samples were collected for hematobiochmical analysis. Midazolam0.6mg/kg induced rapid onset of moderate to deep sedation for 27.67±1.45 min. Injection of another 0.3mg/kgafter ten min. significantly increased the duration of sedation to 95.00±1.15min without affecting the depth ofsedation. Duplication of dose to 1.2mg/kg resulted in rapid onset of deep sedation and recumbancy and theanimal didn't arouse after application of painful stimuli. Midazolam/ketamine combination induced short periodof general anaesthesia lasted for 24.00±2.88 min. with complete muscle relaxation and smooth recovery.In conclusion, midazolam produced dose dependent sedation in goats and its combination with ketamineproduced reliable anaesthesia with good muscle relaxation.
机译：在兽医实践中，单独使用镇静剂或在全身麻醉剂之前使用镇静剂的观念已广为接受。本研究的目的是研究不同剂量的咪达唑仑的临床生理学效应及其作为山羊氯胺酮麻醉前麻醉剂的适用性。三只山羊接受以下一种治疗，间隔一周。咪达唑仑0.6 mg / kg体重，1.2 mg / kg和0.6 mg / kg体重，然后在十分钟后再服用另一剂0.3 mg / kg，最后合并咪达唑仑（0.6 mg / kg）和氯胺酮（4 mg / kg）。记录镇静和卧床的发作，持续时间，镇静程度以及临床参数。收集血样用于血液生物化学分析。咪达唑仑0.6mg / kg诱导中度至深度镇静快速发作27.67±1.45分钟。十分钟后再注射0.3mg / kg。镇静时间显着增加至95.00±1.15min，而不会影响镇静深度。剂量重复至1.2mg / kg会导致深部镇静和卧床迅速发作，并且在施加疼痛刺激后不会引起动物。咪达唑仑/氯胺酮联合诱导的全身麻醉时间短，持续24.00±2.88 min。总之，咪达唑仑在山羊中产生剂量依赖性镇静作用，并且与氯胺酮合用可产生可靠的麻醉效果，并具有良好的肌肉松弛作用。

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