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首页> 外文期刊>Global Veterinaria >Effect of Diclazuril, Semduramicin, Salinomycin and Maduramycin as Preventive Anticoccidial Drugs on Chicken Intestinal Morphology
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Effect of Diclazuril, Semduramicin, Salinomycin and Maduramycin as Preventive Anticoccidial Drugs on Chicken Intestinal Morphology

机译：地克珠利，塞米杜米星，沙利霉素和马杜霉素作为预防性抗球虫药对鸡肠道形态的影响

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摘要

To determine the effect of four anticoccidial drugs, on the normal intestinal mucosa, broiler chickswere reared since they were 1-Day old and treated by diclazuril, semduramicin, salinomycin and maduramycin(1, 20, 60 and 5 mg/kg of diet, respectively) for 3 weeks. Segments from the duodenum, jejunum and ileumwere collected for morphometric analysis. There were negative effects on growth and feed conversion inchickens treated by these drugs after 4 weeks. These drugs decreased villous length, width and surface area,mostly in the duodenum and jejunum. There was also a reduction of the lamina propria thickness in theintestine by anticoccidials except semduramicin which increases lamina propria. The effect of anticoccidialdrugs in the muscle layer was different. It appeared that semduramicin consistently increased it in thethree parts of the intestine. It is concluded that four anticoccidial drugs, diclazuril, semduramicin, salinomycinand maduramycin have adverse effects on chicken performance and intestinal morphology, especially villusdimensions and absorptive surface. There was also evidence for involvement of these drugs in the intestinalmotility and secretion.
机译：为了确定四种抗球虫药对正常肠粘膜的影响，自肉鸡雏鸡出生1天起就对其进行饲养，并分别用地克珠利，塞姆杜米霉素，沙利霉素和马杜霉素治疗（日粮分别为1、20、60和5 mg / kg） ），持续3周。收集十二指肠，空肠和回肠的节段进行形态分析。 4周后，这些药物对生长和饲料转化率下降有不利影响。这些药物减少了绒毛的长度，宽度和表面积，主要在十二指肠和空肠。除球藻霉素外，抗球虫药还可以减少肠道固有层的厚度，从而增加固有层的含量。抗球虫药在肌肉层中的作用是不同的。似乎semduramicin在肠的三个部位持续增加它。结论是，四种抗球虫药，地克珠利，色拉米霉素，沙利霉素和马杜霉素对鸡的生产性能和肠道形态，特别是绒毛尺寸和吸收性表面都有不利影响。也有证据表明这些药物参与肠道运动和分泌。

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