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首页> 外文期刊>Gut and Liver >Increased Risk of Herpes Zoster in Young and Metabolically Healthy Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
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Increased Risk of Herpes Zoster in Young and Metabolically Healthy Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study

机译：青年和代谢健康的肠炎患者中带状疱疹风险增加：一项基于全国人群的研究

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Background/Aims The risk of herpes zoster (HZ) among patients with inflammatory bowel disease (IBD) remains unclear in terms of age and metabolic comorbidities, including diabetes mellitus, hypertension, or dyslipidemia. We conducted a nationwide population-based study to investigate the risk of HZ in patients with IBD. Methods From 2010 to 2013, a retrospective study was performed using claims data in Korea. We compared the incidence of HZ between 30,100 IBD patients (10,517 Crohn’s disease [CD] and 19,583 ulcerative colitis [UC] patients) and 150,500 non-IBD controls matched by age and sex. Results During a mean follow-up of 5.0 years, incidence rates of HZ (per 1,000 person-years) were 13.60, 14.99, and 9.19 in the CD, UC, and control groups, respectively. The risk of HZ was significantly higher in patients with CD (adjusted hazard ratio [HR], 2.13; p&0.001) and UC (adjusted HR, 1.40; p&0.001) than in the controls. The impact of CD on developing HZ was significantly more prominent in younger patients (adjusted HR, 2.61 for age &15, whereas 1.39 for age ≥60; interaction p=0.001) and in patients without metabolic comorbidities (adjusted HR, 2.24, whereas 1.59 in those with metabolic comorbidities; interaction p=0.015). Moreover, the impact of UC on developing HZ significantly increased in younger patients (adjusted HR, 2.51 in age &15, whereas 1.22 in age ≥60; interaction p=0.014) and patients without metabolic comorbidities (adjusted HR, 1.49 whereas 1.16 in those with metabolic comorbidities; interaction p&0.001). Conclusions IBD was associated with an increased risk of HZ, especially in younger patients without metabolic comorbidities.
机译：背景/目的炎症性肠病（IBD）患者的带状疱疹（HZ）风险在年龄和代谢合并症（包括糖尿病，高血压或血脂异常）方面仍不清楚。我们在全国范围内进行了一项基于人群的研究，以调查IBD患者的HZ风险。方法从2010年至2013年，使用韩国的索赔数据进行了回顾性研究。我们比较了30100例IBD患者（10517例克罗恩病[CD]和19583例溃疡性结肠炎[UC]患者）和150500例按年龄和性别匹配的非IBD对照者的HZ发生率。结果在平均5.0年的随访中，CD，UC和对照组的HZ发生率（每1,000人年）分别为13.60、14.99和9.19。 CD（调整后的危险比[HR]，2.13; p ＜0.001）和UC（调整后的HR，1.40; p ＜0.001）患者的HZ风险明显高于对照组。 CD对发展中的HZ的影响在年轻患者中（校正后的HR，对于<15岁的患者为2.61，而对于≥60岁的患者为1.39;相互作用p = 0.001）和无代谢合并症的患者（校正后的HR，2.24，而在患有合并症的患者中为1.59;相互作用p = 0.015）。此外，UC对年轻患者（校正后的HR，2.51 ＜15岁，而1.22≥60岁;交互作用p = 0.014）和无代谢合并症的患者（校正后的HR，1.49而1.16例，则显着增加）。具有代谢合并症的患者;相互作用p ＜0.001）。结论IBD与HZ风险增加有关，尤其是在没有代谢合并症的年轻患者中。

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