...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gut and Liver >Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis
【24h】

Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis

机译：血浆K18片段水平与酒精性肝纤维化不相关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aims Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of liver disease. The aim of this study was to correlate plasma M30 levels with stages of liver fibrosis in ALD. Methods Patients with ALD (n=139, 79.1% males) and liver histology were included, and plasma samples were collected to quantify plasma M30 levels. Patients were stratified into five groups by fibrosis stage (F0=14; F1=15; F2=35; F3=17; and F4=58) according to the Kleiner score. Differences between groups were evaluated using the chi-square test or analysis of variance. Trends by fibrosis stage were calculated by logistic regression analysis, and sensitivity, specificity and positive and negative predictive values were determined. Results There were no significant differences in M30 levels among fibrosis stages. The correlation between plasma M30 levels and fibrosis was poor (Pearson’s correlation coefficient=0.13, Spearman rho=0.20 [p=0.02]), and M30 levels did not correlate with alcohol-specific histological features. However, significant correlations of M30 levels with aspartate aminotransferase (Spearman rho=0.653, p&0.001) and alanine aminotransferase (Spearman rho=0.432, p&0.001) were found. M30 levels of &200 U/L reveal a sensitivity for predicting cirrhosis of 84.5% with a negative predictive value of 73.5%. Conclusions Plasma M30 levels are often elevated in ALD and correlate with serum transaminases but do not reflect fibrosis. The usefulness as a prognostic marker awaits evaluation in prospective studies.
机译：背景/目的酒精性肝病（ALD）中肝纤维化的非侵入性标记对于建立早期干预至关重要。先前的研究表明，血浆中切割的角蛋白18（K18; M30）片段的水平可以预测肝病的严重程度。这项研究的目的是将血浆M30水平与ALD中肝纤维化的阶段联系起来。方法包括ALD患者（n = 139，男性占79.1％）和肝脏组织学，并收集血浆样本以定量血浆M30水平。根据Kleiner评分，按纤维化阶段将患者分为五组（F0 = 14; F1 = 15; F2 = 35; F3 = 17; F4 = 58）。使用卡方检验或方差分析评估组之间的差异。通过逻辑回归分析计算纤维化阶段的趋势，并确定敏感性，特异性以及阳性和阴性预测值。结果在纤维化阶段之间，M30水平没有显着差异。血浆M30水平与纤维化之间的相关性较弱（Pearson相关系数= 0.13，Spearman rho = 0.20 [p = 0.02]），并且M30水平与酒精特定的组织学特征无关。然而，发现M30水平与天冬氨酸氨基转移酶（Spearman rho ＝ 0.653，p ＜0.001）和丙氨酸氨基转移酶（Spearman rho ＝ 0.432，p ＜0.001）具有显着相关性。 ≥200U/ L的M30水平显示出84.5％的预测肝硬化的敏感性和73.5％的阴性预测值。结论ALD中血浆M30水平经常升高，与血清转氨酶相关，但不能反映纤维化。作为预后指标的有用性正在等待前瞻性研究的评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号