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A cautionary note regarding detection of PD-L1 expression by tumour-associated macrophages

机译:关于通过肿瘤相关巨噬细胞检测PD-L1表达的注意事项

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We read with interest the recent paper by Gottlieb et al. (2017) in which the authors evaluated Programmed Death Ligand-1 (PD-L1) expression by tumour cells and tumour-associated macrophages (TAMs) in primary high grade serous ovarian cancer (HGSOC) specimens and in matched metastases. The expression of immune checkpoint molecules in the local tumour environment, particularly of PD-L1, is currently a topic of much research focus. However, there are some technical issues surrounding the immunohistochemical detection of PD-L1 that other researchers who are considering performing this assay should be aware of. These are especially important in the context of TAM PD-L1 expression.
机译:我们感兴趣地阅读了Gottlieb等人的最新论文。 (2017),作者评估了原发性高级别浆液性卵巢癌(HGSOC)标本和转移灶中肿瘤细胞和与肿瘤相关的巨噬细胞(TAM)的程序性死亡配体1(PD-L1)表达。免疫检查点分子在局部肿瘤环境中,特别是在PD-L1中的表达,目前是许多研究热点。但是,PD-L1的免疫组织化学检测存在一些技术问题,其他正在考虑执行此测定法的研究人员应注意这些问题。这些在TAM PD-L1表达的背景下尤其重要。

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