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首页> 外文期刊>Gynecologic Oncology Reports >Three cases of women with HPV-related squamous cell carcinoma of unknown primary in the pelvis and retroperitoneum: A case series
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Three cases of women with HPV-related squamous cell carcinoma of unknown primary in the pelvis and retroperitoneum: A case series

机译：女性骨盆和腹膜后原发性不明HPV相关鳞状细胞癌3例：病例系列

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Background Carcinoma of unknown primary (CUP) of the pelvis is a challenging entity for the oncologist. The role of human papilloma virus (HPV)/p16 in carcinogenesis and prognosis is more established in the head and neck than in the pelvis. In the case of an HPV positive occult primary of the pelvis the radiation therapy target coverage is not well established. Case reports Case#1: A 69-year-old female with a left retroperitoneal and pelvic mass was treated with chemoradiation to a dose of 45 Gy in 25 fractions to elective lymph node regions and simultaneous boost to FDG-avid lymph nodes to 55 Gy in 25 fractions. A post-treatment PET-CT showed complete response of disease now 7 months post treatment. Case#2: A 58-year-old female with a large left retroperitoneal pelvic mass was treated post-operatively with chemoradiation to 45 Gy in 25 fractions with a pelvic boost to 54 Gy. She is clinically and radiographically with no evidence of disease at 4 years. Case#3: A 47-year-old female with left sided retroperitoneal pelvic mass that declined therapy. She ultimately died of progressive disease at 1 year after diagnosis. Conclusion Cisplatin based chemoradiation is effective for treating HPV/p16 + pelvic squamous cell cancers of unknown primary as long as the mass, regional lymph nodes and high risk pelvic primary sites are adequately covered. Highlights ? Adds 3 cases of pelvic squamous cell carcinoma of unknown primary ? Similarities between pelvic and head and neck squamous cell of unknown primary ? Radiation to highest risk sites of primary disease important ? Prognosis not as bad as previously shown with aggressive chemoradiation.
机译：背景骨盆未知原发性癌（CUP）对肿瘤科医生来说是具有挑战性的实体。人乳头瘤病毒（HPV）/ p16在癌变和预后中的作用在头颈部比在骨盆中更为明确。如果是骨盆HPV阳性隐匿性原发灶，则放射治疗的靶标覆盖率尚不明确。病例报告病例＃1：一名左腹膜后和骨盆肿块的69岁女性接受化学放射治疗，剂量为45 Gy（分25个部分）至选择性淋巴结区域，同时将FDG-avid淋巴结增强至55 Gy分25个部分治疗后的PET-CT现已显示出治疗后7个月内疾病的完全缓解。案例2：一名58岁的女性，腹膜后部左腹骨块较大，术后25个小时接受化学放疗至45 Gy，盆腔增强至54 Gy。她在临床和影像学上在4岁时无疾病迹象。案例3：一名47岁女性，左侧腹膜后盆腔肿块拒绝治疗。诊断后一年，她最终死于进行性疾病。结论只要能充分覆盖肿块，区域淋巴结和高危盆腔原发灶，基于顺铂的化学放射治疗对未知原发性HPV / p16 +盆腔鳞状细胞癌有效。强调 ？新增3例原发性未知的盆腔鳞癌。未知原发性骨盆与头颈鳞状细胞之间的相似性？辐射到原发疾病的最高风险部位重要吗？预后不如先前用积极的化学放疗显示的差。

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