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首页> 外文期刊>eNeurobiologia >Effects of oxytocin on pubococcygeous motoneurons of male rats with spinal cord injury
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Effects of oxytocin on pubococcygeous motoneurons of male rats with spinal cord injury

机译：催产素对雄性大鼠脊髓损伤的耻骨运动神经元的影响

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Introduction: Previous studies have demonstrated that length of primary dendrites and area of neuronal soma were reduced in rat Pubococcygeous muscle motoneurons after spinal cord injury, and oxytocin enhanced these parameters. The present study analyzed primary dendrite number-stained and length of secondary dendrites of Pubococcygeous motoneurons after spinal cord injury and treatment with oxytocin.Objectives: To determine the effect of oxytocin on these morphological characteristics in motoneurons stained with WGA-HRP following spinal cord injury.Material and Methods: Adult male rats Wistar were used and grouped in: intact of spinal cord with intrathecal implant during 4 weeks (INT); 2 weeks of spinal cord-lesion with intrathecal implant-and treatment with saline solution (LE-TS) during 2 weeks more; 2 weeks of spinal cord-lesion and treatment with oxytocin during 2 weeks more (LE-TOx). Pubococcygeous motoneurons were retrogradely stained with WGA-HRP and subjected to a morphological analysis. Data were analyzed by using a one way ANOVA followed by a Dunnet’s post hoc test in order to determine statistical significance (p
机译：简介：先前的研究表明，脊髓损伤后大鼠耻骨球肌运动神经元的原发树突长度和神经元体细胞面积减少，催产素增强了这些参数。本研究分析了脊髓损伤并用催产素治疗后的耻骨运动神经元的初级树突数量染色和次级树突的长度。目的：确定催产素对脊髓损伤后WGA-HRP染色的运动神经元这些形态特征的影响。材料和方法：使用成年雄性大鼠Wistar并分组为：4周内（INT）完整鞘内植入脊髓。鞘内植入2周脊髓损伤-并在2周内用盐溶液（LE-TS）治疗;脊髓病变2周，并在2周内使用催产素治疗（LE-TOx）。用WGA-HRP对耻骨球运动神经元进行逆向染色，并进行形态分析。为了确定统计显着性，使用单向方差分析和Dunnet事后检验对数据进行了分析。

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