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首页> 外文期刊>eNeurologicalSci >Antiepileptic drugs in development pipeline: A recent update
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Antiepileptic drugs in development pipeline: A recent update

机译：抗癫痫药正在开发中：最新更新

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Epilepsy is the most common neurological disorder which significantly affects the quality of life and poses a health as well as economic burden on society. Epilepsy affects approximately 70 million people in the world. The present article reviews the scientific rationale, brief pathophysiology of epilepsy and newer antiepileptic drugs which are presently under clinical development. We have searched the investigational drugs using the key words ‘antiepileptic drugs,’ ‘epilepsy,’ ‘Phase I,’ ‘Phase II’ and ‘Phase III’ in American clinical trial registers ( clinicaltrials.gov ), the relevant published articles using National Library of Medicine's PubMed database, company websites and supplemented results with a manual search of cross-references and conference abstracts. This review provides a brief description about the antiepileptic drugs which are targeting different mechanisms and the clinical development status of these drugs. Besides the presence of old as well as new AEDs, still there is a need of new drugs or the modified version of old drugs in order to make affected people free of seizures. An optimistic approach should be used to translate the success of preclinical testing to clinical practice. There is an urgent need to improve animal models and to explore new targets with better understanding in order to develop the novel drugs with more efficacy and safety. Highlights ? This review primarily focused on antiepileptic drugs under clinical development. ? The more realistic approach is needed to discover and develop the novel antiepileptic drugs. ? Modification of conventional drugs or search of newer targets can lead to development of promising antiepileptic drugs. ? To develop more efficacious and safe drugs for treatment of epilepsy and refractory seizures ? There are a number of novel antiepileptic compounds which are under various stages of drug development.
机译：癫痫病是最常见的神经系统疾病，会严重影响生活质量，给社会带来健康和经济负担。癫痫病影响了全世界大约7000万人。本文综述了目前正在临床开发中的癫痫的科学原理，简短的病理生理学和新型抗癫痫药。我们在美国临床试验注册簿（clinicaltrials.gov）中使用关键词“抗癫痫药”，“癫痫病”，“ I期”，“ II期”和“ III期”来搜索研究用药物，并使用National医学图书馆的PubMed数据库，公司网站以及通过手动搜索交叉引用和会议摘要而得到的补充结果。这篇综述提供了针对抗癫痫药物的简要描述，这些药物针对不同的机制以及这些药物的临床发展状况。除了旧的和新的AEDs之外，仍然需要新药或旧药的改良版，以使受影响的人免于癫痫发作。应该使用乐观的方法将临床前测试的成功转化为临床实践。迫切需要改善动物模型并更好地了解新的靶标，以便开发出具有更高功效和安全性的新药。强调 ？这篇综述主要针对临床开发中的抗癫痫药。 ？需要更现实的方法来发现和开发新型抗癫痫药。 ？常规药物的改良或寻找新的靶标可导致开发有前途的抗癫痫药。 ？开发更有效，更安全的治疗癫痫和难治性癫痫的药物？有许多处于药物开发各个阶段的新型抗癫痫化合物。

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