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首页> 外文期刊>eNeurologicalSci >Subcortical Vascular Cognitive Impairment staged through cdr's functional subsum (cdr-func): Preliminary results from an outpatient sample
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Subcortical Vascular Cognitive Impairment staged through cdr's functional subsum (cdr-func): Preliminary results from an outpatient sample

机译：通过cdr的功能性总和（cdr-func）分期进行的皮层下血管认知障碍：门诊样本的初步结果

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Background Staging vascular cognitive impairment (VCI) might be useful for sample selection in clinical trials and for guiding clinical decision-making. Clinical dementia rating (CDR) has been applied for staging cognitive impairments of different etiologies, but it may underestimate severity of non-Alzheimer's disease cognitive deficits. Methods Out of a total of 147 elderly subjects, 23 (mean age: 72.95 ± 7.51 years; 56% female; mean schooling: 9.52 ± 5.11 years) fulfilled clinical and neuroimaging criteria for VCI. Correlations among cognitive and functional status and scores in CDR and its subsums (CDR Sum of Boxes – CDR-SoB - and CDR Functional Subsum – CDR-FUNC) were performed. Results Both CDR-SoB and CDR-FUNC correlated with global cognitive performance, functional status, CLOX 2, working memory and abstraction tests. CDR global score only correlated with functional status. Discussion CDR-FUNC, as well as CDR-SoB, appear to be better indexes of severity in VCI than CDR global score. Highlights ? The CDR's Functional Subsum is proposed for staging vascular cognitive impairment. ? CDR-FUNC correlated with scores in executive tasks, whereas CDR total score did not. ? CDR-FUNC might be a better tool for staging vascular cognitive impairment than CDR.
机译：背景血管性认知障碍（VCI）分期对于临床试验中的样本选择和指导临床决策可能有用。临床痴呆评分（CDR）已被用于分期不同病因的认知障碍，但它可能低估了非阿尔茨海默氏病认知障碍的严重程度。方法在147位老年受试者中，有23位（平均年龄：72.95±7.51岁;女性56％;平均受教育程度：9.52±5.11岁）符合VCI的临床和神经影像学标准。进行了认知和功能状态与CDR及其总和（CDR总和-CDR-SoB-和CDR功能总和-CDR-FUNC）之间的相关性。结果CDR-SoB和CDR-FUNC均与整体认知表现，功能状态，CLOX 2，工作记忆和抽象测试相关。 CDR总体评分仅与功能状态相关。讨论CDR-FUNC和CDR-SoB在VCI中的严重程度指标似乎比CDR全局评分更好。强调 ？ CDR的功能性总和被提议用于分期血管性认知障碍。 ？ CDR-FUNC与执行任务的分数相关，而CDR总分数则不相关。 ？与CDR相比，CDR-FUNC可能是更好的分期血管性认知障碍的工具。

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