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>Submucosal Injection of Normal Saline can Prevent Unexpected Deep Thermal Injury of Argon Plasma Coagulation in the in vivo Porcine Stomach
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Submucosal Injection of Normal Saline can Prevent Unexpected Deep Thermal Injury of Argon Plasma Coagulation in the in vivo Porcine Stomach
Background/Aims: There have been several reports of thermal injury induced by argon plasma coagulation (APC) in animal models, but no follow-up studies have revealed the actual thermal injury. Methods: APC was performed on the stomachs of two living minipigs with and without prior submucosal injection of normal saline. The power and argon gas flow were set to 60 watts and 2 L/min, respectively, and pulse durations of 5, 10, and 20 seconds were used. One of the minipigs was killed immediately thereafter and the other was killed 1 week later. Results: The minipig killed immediately showed only subtle differences between noninjected and injected injuries under all the conditions, and the usefulness of prior submucosal injection was not obvious. However, the minipig killed 1 week later had a deep ulcer extending to the deeper muscle layer at the noninjected site where APC had been applied for 20 seconds, whereas tissue injury of the injected site was limited to the submucosal layer. Conclusions: Unexpected tissue damage can occur even using a short-duration APC. Prior submucosal injection for APC might be a safer alternative technique, especially in a thinner and narrower gut wall. (Gut and Liver 2008;2:95-98)
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机译：背景/目的：在动物模型中，已有几篇关于氩等离子体凝结（APC）引起的热损伤的报道，但没有后续研究显示出实际的热损伤。方法：在两只活着的小猪的胃中进行APC，有或没有事先粘膜下注射生理盐水。功率和氩气流量分别设置为60瓦特和2 L / min，并使用5、10和20秒的脉冲持续时间。一头迷你猪此后立即被杀死，另一只在1周后被杀死。结果：在所有情况下，立即杀死的小型猪在未注射和注射伤害之间仅表现出细微的差别，并且先前黏膜下注射的用处不明显。然而，在一周后杀死的小型猪在未注射的部位（其应用了APC的时间为20秒）有一个深溃疡，延伸到较深的肌肉层，而注射部位的组织损伤仅限于粘膜下层。结论：即使使用短期APC，也可能发生意外的组织损伤。事先为APC进行粘膜下注射可能是一种更安全的替代技术，尤其是在肠壁更薄更窄的情况下。 （肠道和肝脏2008; 2：95-98）
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