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首页> 外文期刊>eNeurologicalSci >Ischemic stroke as initial manifestation of systemic lupus erythematosus: A case report and review of the literature
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Ischemic stroke as initial manifestation of systemic lupus erythematosus: A case report and review of the literature

机译：缺血性卒中为系统性红斑狼疮的初步表现：一例病例报告并文献复习

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Stroke is a frequent occurrence among patients suffering from systemic lupus erythematosus (SLE), but it rarely occurs as the initial manifestation of the disease. We here present the case of a 37?year-old patient who developed an acute cerebellar ischemic stroke as initial event of SLE: elevated partial thromboplastin time and ESR, thrombocytopenia, anti-ds-DNA, anti-SSA, anti-JO-1, and the lupus anticoagulant were detected, and the diagnosis of SLE was established. In addition, we reviewed the literature in order to clarify the demographic, clinical, imaging and outcome characteristics of such a presentation, and found 10 similar cases. Most patients were young (age 31.7?±?8.5?years) and women (8/11, 72.7%). Stroke most often affected the vertebrobasilar territory (7/11, 63.6%). The stroke mechanism was not clearly defined in these cases. Treatment with immunosuppression and anticoagulation was considered to be a reasonable choice for early secondary stroke prevention. The occurrence of ischemic stroke, primarily in the vertebrobasilar system among young patients, especially women, should always raise suspicion for underlying SLE, and prompt diagnostic investigations to confirm or exclude its presence.
机译：中风是患有系统性红斑狼疮（SLE）的患者中经常发生的现象，但很少作为疾病的初始表现而发生。我们在这里介绍了一个37岁的患者，该患者发生了急性小脑缺血性卒中作为SLE的初始事件：部分凝血活酶时间和ESR升高，血小板减少，抗ds-DNA，抗SSA，抗JO-1 ，并检测出狼疮抗凝剂，并建立了SLE的诊断。此外，我们回顾了文献以阐明此类表现的人口统计学，临床，影像学和预后特征，并发现了10个类似病例。大多数患者为年轻（年龄31.7±8.5年）和女性（8 / 11，72.7％）。中风最常累及椎基底基底区域（7 / 11，63.6％）。在这些情况下，中风机制尚不明确。免疫抑制和抗凝治疗被认为是早期继发中风预防的合理选择。缺血性中风的发生，主要是在年轻患者（尤其是女性）的椎基底基底系统中，应始终怀疑潜在的SLE，并应进行诊断检查以确认或排除其存在。

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