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Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects

机译：特发性颅内高压患者的脑脊液压力波形和颅骨顺应性特征

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Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p?
机译：特发性颅内高压症（IIH）是病因不明的异常高颅内压疾病。这项研究的目的是表征颅脊椎顺应性并测量脑脊液（CSF）压力波形，因为在IIH诊断性和治疗性腰椎穿刺（LP）期间CSF被动引流。符合改良丹迪标准（包括乳头状浮肿和视野丧失）的18名受试者接受了超声引导的LP，其中在每次CSF去除增量时记录了CSF压力（CSFP）。连接点回归模型用于计算CSF压力的依从性，并针对每个受试者在每次增加时删除相应的体积。用电子传感器记录了十二名受试者的CSFP波形。还计算了体重指数，平均CSFP和脑灌注压（CPP）。使用T检验比较测量结果，并在参数之间进行关联。发现LP前后，脑脊液压力，CSFP脉搏振幅（CPA）和CPP有显着差异（p≤0.05）。 LP之后，CSFP和CPA下降，而CPP上升。 LP后颅骨的顺应性显着增加（p <0.05）。 CPA和CSFP呈显着正相关。确定了低颅骨顺应性（在高CSFP时）和高颅骨顺应性（在CSFP时）区域。表征了IIH中的CSFP波形形态，发现CPA与CSFP的大小呈正相关。未来的研究将调查IIH受试者中颅脊柱顺应性如何与症状和/或对治疗的反应相关。

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