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首页> 外文期刊>Folia histochemica et cytobiologica >The immunohistochemical demonstration of parafollicular cells and evaluation of calcium-phosphate balance in patients with thyroid hemiagenesis
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The immunohistochemical demonstration of parafollicular cells and evaluation of calcium-phosphate balance in patients with thyroid hemiagenesis

机译：甲状腺造血患者卵泡旁细胞的免疫组织化学表现及磷酸钙平衡的评估

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Thyroid hemiagenesis (TH) is characterized by the congenital absence of one thyroid lobe. The aim of this study was to evaluate the calcium-phosphate balance in TH. Twenty patients with TH and 20 controls with a bilobed thyroid were studied. Serum concentrations of total calcium, parathormon and calcitonin were measured. Additionally, the immunohistochemical expression of calcitonin, chromogranin A (chA), neuron-specific enolase (NSE) and calcitonin gene-related peptide (CGRP) was evaluated in surgical specimens from patients with TH and controls. There were no significant differences in biochemical parameters between TH and controls. Positive staining for calcitonin was demonstrated in 3/8 thyroid sections from three patients with TH, but only in 2/33 sections from four controls (p < 0.005). All sections from patients with TH positive for calcitonin also expressed chA, NSE and CGRP. Two sections from controls positive for calcitonin presented an additionally positive reaction for chA, and one of them also for NSE. None presented positive staining for CGRP. Of three TH sections, in one, hyperplasia of C cells of medium grade, and in another hyperplasia of C cells of high grade, could be detected. In the controls, hyperplasia of C cells of low and medium grade was observed. TH was associated with slightly enhanced C cells hyperplasia compared to controls, which might indicate compensatory proliferation. However, the calcium-phosphate balance does not seem to be significantly affected. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 299–305)
机译：甲状腺造血（TH）的特征是先天性没有一个甲状腺叶。这项研究的目的是评估TH中的磷酸钙平衡。研究了20例TH患者和20例甲状腺双叶对照患者。测量血清总钙，副甲状腺激素和降钙素的浓度。此外，在TH患者和对照患者的手术标本中评估了降钙素，嗜铬粒蛋白A（chA），神经元特异性烯醇化酶（NSE）和降钙素基因相关肽（CGRP）的免疫组织化学表达。 TH和对照之间的生化参数没有显着差异。三名TH患者的3/8甲状腺切片显示降钙素阳性染色，但四名对照仅2/3切片显示降钙素阳性（p <0.005）。降钙素TH阳性的患者的所有切片均表达chA，NSE和CGRP。降钙素阳性对照的两部分对chA表现出另外的阳性反应，其中之一对NSE也呈阳性反应。没有人呈现CGRP阳性染色。在三个TH切片中，可以检测到一个中度C细胞的增生，而另一个可以检测高度C细胞的增生。在对照中，观察到中低级C细胞的增生。与对照组相比，TH与C细胞增生略有增强有关，这可能表明代偿性增生。但是，磷酸钙的平衡似乎并未受到明显影响。 （Folia Histochemica et Cytobiologica 2011;第49卷，第2期，第299-305页）

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